This is a list of investigational other psychiatric disorder drugs, or drugs that are currently under development for clinical use for the treatment of other or unspecified psychiatric disorders but are not yet approved. Some examples of such conditions include adjustment disorders, behavioral disorders, behavioral addictions like gambling addiction, impulse–control disorders, other personality disorders, and somatoform disorders. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action – Indication [Reference]". This list was last comprehensively updated in January 2026. It is likely to become outdated with time.
Under development
Phase 3 Lumateperone (Caplyta; ITI-007; ITI-722) – non-selective monoamine receptor modulator – behavioral disorders [1] Lurasidone (DSP-1349M; Latuda; SM-13496; SMP-13496) – atypical antipsychotic (non-selective monoamine receptor modulator) – psychiatric disorders [2] Ralmitaront (NTX-2001; RG-7906; RO-6889450) – trace amine-associated receptor 1 (TAAR1) agonist – psychiatric disorders [3] Venlafaxine extended-release (ALM-002; ALM002) – undefined mechanism of action – mental disorders [4] [5]
Phase 2/3 Evenamide (NW-3509; NW-3509A) – sodium channel blocker – psychiatric disorders [6] Psilocybin (CYB001; CYB-001; INT0052/2020) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, serotonergic psychedelic – mental disorders [7]
Phase 2 ALM-007 (ALM007) – undefined mechanism of action – psychiatric disorders [8] [9] Deudextromethorphan (AVP-786; CTP-786; d-DM; deuterated-DM; deuDXM; deu-DXM; deuterated DXM) – NMDA receptor antagonist, sigma receptor agonist, other actions – impulse–control disorders [10] Fasedienol (Aloradine; AM-005; PH-94B; PH94B) – vomeropherine (chemoreceptor cell modulator) – adjustment disorders [11] Psilocybin (COMP360; COMP-360) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, serotonergic psychedelic – somatoform disorders [12] Psilocybin (PEX-010) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, serotonergic psychedelic – adjustment disorders [13] SRX-246 (SRX246; API-246) – vasopressin V1A receptor antagonist – impulse–control disorders [14] SXC-2023 – cystine–glutamate antiporter (SLC7A11; System xc- or Sxc) activator – impulse–control disorders [15] [16]
Phase 1/2 SRX-246 (SRX246; API-246) – vasopressin V1A receptor antagonist – behavioral disorders [17]
Phase 1 5-MeO-MiPT (MSD-001; MS001; MSD-101; MSD-201; MSD-X01) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, serotonergic psychedelic – mental disorders [18] CVN-766 (CVN766) – orexin OX1 receptor antagonist – psychiatric disorders [19] "Glutamate receptor modulator" - Boehringer Ingelheim – glutamate receptor modulator – mental disorders [20] KNX-100 (KNX100; SOC-1) – oxytocin-like drug / indirect oxytocin receptor modulator – behavioral disorders [21] MSP-2020 (MSP2020) – serotonin 5-HT2A receptor agonist – mental disorders [22] [23] NBI-1140675 – vesicular monoamine transporter 2 (VMAT2) inhibitor – psychiatric disorders [24] Radiprodil (RGH-896) – ionotropic glutamate NR2B-containing NMDA receptor antagonist – behavioral disorders [25] "Receptor agonist" - Boehringer Ingelheim – undefined mechanism of action – mental disorders [26] SYT-510 (SYT510) – endocannabinoid reuptake inhibitor – psychiatric disorders [27]
Clinical phase unknown Eplivanserin/volinanserin – fixed-dose combination of eplivanserin (serotonin 5-HT2A receptor antagonist) and volinanserin (serotonin 5-HT2A receptor antagonist) – psychiatric disorders [28] [29]
Preclinical Aripiprazole controlled release (LYN-006; ultra long-acting aripiprazole) – atypical antipsychotic (non-selective monoamine receptor modulator) – psychiatric disorders [30] CYB-210010 (CYB210010; 2C-T-TFM; 2C-T-36) – serotonin 5-HT2 receptor agonist and serotonergic psychedelic – psychiatric disorders [31] Dexmedetomidine (BXCL-501; Igalmi; KalmPen) – α2-adrenergic receptor agonist – psychiatric disorders [32] DT-201 (DT201) – α5 subunit-containing GABAA receptor negative allosteric modulator – psychiatric disorders [33] KAR-501 (KAR501) – undefined mechanism of action – mental disorders [34] Lu AG06474 (Lu-AG-06474) – monoacylglycerol lipase (MAGL) inhibitor – psychiatric disorders [35] Metyrapone/oxazepam (EMB-001C; EMB-001) – combination of metyrapone (11β-hydroxylase inhibitor and cortisol synthesis inhibitor) and oxazepam (benzodiazepine/GABAA receptor positive allosteric modulator) – gambling [36] NBI-1065890 (NBI-890) – vesicular monoamine transporter 2 (VMAT2) inhibitor – psychiatric disorders [37] ORX-489 (ORX489) – orexin OX2 receptor antagonist – psychiatric disorders [38] OV-350 (AZ-8333) – potassium–chloride-cotransporter agonist – psychiatric disorders [39] TPT-0301 (neuropathic pain therapeutic) – cannabinoid receptor modulator – mental disorders [40]
Research OWP-107 (OWP107) – undefined mechanism of action – psychiatric disorders [41] Psilocybin (REL-P11) – non-selective serotonin receptor agonist, serotonin 5-HT2A receptor agonist, serotonergic psychedelic – psychiatric disorders [42] Research programme: mental disorder therapies - Mindstate Design Labs (MSD-X02) – undefined mechanism of action – mental disorders [43]
Not under development
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