science

List of investigational sex-hormonal agents

List of investigational sex-hormonal agents is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational sex-hormonal agents rather than just read about it. In short: This is a list of investigational sex-hormonal agents, or sex-hormonal agents that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Key takeaways

List of investigational sex-hormonal agents belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect List of investigational sex-hormonal agents to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of List of investigational sex-hormonal agents from memory before moving on to harder problems.

Reference excerpt

This is a list of investigational sex-hormonal agents, or sex-hormonal agents that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. This list was last comprehensively updated sometime between May 2017 and September 2021. It is likely to become outdated with time.

Androgenics

Androgen receptor agonists Deuterated testosterone (AVA-291; AVA291; d3-testosterone; d3-T; testosterone-19-d3) – deuterated and highly aromatase-resistant testosterone analogue with little/no estrogenic activity EC586 – oral prodrug of testosterone (androgen/anabolic steroid) with improved pharmacokinetics

Selective androgen receptor modulators DT-200 (G-100192, GLPG-0492) – selective androgen receptor modulator for Duchenne muscular dystrophy Enobosarm (ostarine; GTx-024, MK-2866; S-22; VERU-024) – selective androgen receptor modulator for breast cancer GSK-2881078 – selective androgen receptor modulator for cachexia OPK-88004 (LY-2452473; OPK-88004; TT-701) – selective androgen receptor modulator for benign prostatic hyperplasia, erectile dysfunction, and prostate cancer VK-5211 (LGD-4033; ligandrol) – selective androgen receptor modulator for hip fracture and muscle atrophy Vosilasarm (EP-0062, RAD-140; testolone) – selective androgen receptor modulator for breast cancer

Androgen receptor antagonists Bavdegalutamide (AVR-110) – androgen receptor antagonist for prostate cancer Clascoterone (CB-03-01, Breezula, Winlevi) – androgen receptor antagonist for topical treatment of scalp hair loss Deutenzalutamide (deuterated enzalutamide; HC-1119) – androgen receptor antagonist for prostate cancer Pruxelutamide (GT-0918; proxalutamide) – androgen receptor antagonist for prostate cancer Pyrilutamide (KX-826) – androgen receptor antagonist for topical treatment of androgen-dependent scalp hair loss and acne Spironolactone (Aldactone) – androgen receptor antagonist for systemic treatment of acne

Atypical androgen receptor antagonists Dimethylcurcumin (ASC-J9) – androgen receptor degradation enhancer for topical acne treatment Masofaniten (EPI-7386) – N-terminal domain androgen receptor antagonist for prostate cancer Rosolutamide (ASC-JM17, JM17, ALZ-003) – androgen receptor degradation enhancer

Androgen synthesis inhibitors Seviteronel (VT-464) – CYP17A1 inhibitor (androgen synthesis inhibitor) for prostate cancer and breast cancer

Estrogenics

Estrogen receptor agonists EC508 – oral prodrug of estradiol (estrogen) with improved pharmacokinetics Erteberel (LY-500307, SERBA-1) – selective ERβ agonist for schizophrenia Estetrol (Donesta) – estrogen for menopausal symptoms and other indications

Selective estrogen receptor modulators Acolbifene (EM-652, SCH-57068) – selective estrogen receptor modulator for breast cancer Afimoxifene (4-hydroxytamoxifen; 4-OHT; TamoGel) – selective estrogen receptor modulator for topical treatment of breast cancer and hyperplasia Amcenestrant (SAR-439859; SERD '859) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer Camizestrant (AZ14066724, AZD-9833) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer Endoxifen (4-hydroxy-N-desmethyltamoxifen) – selective estrogen receptor modulator for breast cancer Giredestrant (GDC-9545; RG-6171) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer Imlunestrant (LY-3484356) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer and endometrial cancer Rintodestrant (G1T-48) – selective estrogen receptor modulator and selective estrogen receptor degrader for breast cancer

Estrogen receptor antagonists Fulvestrant-3 boronic acid (ZB716) – estrogen receptor antagonist (antiestrogen) for breast cancer

Estrogen synthesis inhibitors Estradiol sulfamate (E2MATE, J995, PGL-2, PGL-2001, ZK-190628) – steroid sulfatase inhibitor (estrogen "activation" inhibitor) for endometriosis Leflutrozole (BGS-649) – aromatase inhibitor (estrogen synthesis inhibitor) for male hypogonadism

Progestogenics

Progesterone receptor agonists Hydroxyprogesterone caproate (LPCN-1107) – oral progesterone receptor agonist (progestogen/progestin) for prevention of preterm labor VOLT-02 – water-soluble conjugate of progesterone and neurosteroid for traumatic brain injury and gynecological disorders

Selective progesterone receptor modulators Telapristone (CDB-4124, Proellex, Proellex-V, Progenta) – selective progesterone receptor modulator for breast cancer, endometriosis, and uterine fibroids Vilaprisan (BAY-1002670) – selective progesterone receptor modulator for endometriosis and uterine fibroids

Progesterone receptor antagonists Onapristone (AR-18, IVV-1001, ZK-299, ZK-98299) – progesterone receptor antagonist (antiprogestogen) for prostate cancer

GnRH/gonadotropins

GnRH receptor antagonists Merigolix (HS-10518, NCE-403, SKI-2670, TU-2670) – small-molecule GnRH antagonist for endometriosis and uterine fibroids

Kisspeptin receptor agonists MVT-602 (RVT-602, TAK-448) – small-molecule kisspeptin receptor agonist for female infertility and hypogonadism

Neurokinin/tachykinin receptor antagonists Elinzanetant (BAY-3427080; GSK-1144814; NT-814) – small-molecule NK1 receptor and NK3 receptor antagonist for hot flashes and "sex hormone disorders"

Mixed/combinations

Androgen and progesterone receptor modulators 11β-Methyl-19-nortestosterone dodecylcarbonate (CDB-4754) – dual androgen/anabolic steroid and progestin for use as a male birth control pill Dimethandrolone undecanoate (CDB-4521) – dual androgen/anabolic steroid and progestin for use as a male birth control pill

Androgen and estrogen receptor modulators Acolbifene/prasterone (Femivia) – selective estrogen receptor modulator and dehydroepiandrosterone supplement for hot flashes

Androgen, estrogen, and progesterone receptor modulators Ethinylestradiol/drospirenone/prasterone – estrogen, progestogen, and dehydroepiandrosterone combination for female birth control

See also List of investigational drugs List of investigational PMS/PMDD drugs

References

External links AdisInsight - Springer 2011 Medicines in Development for Women - PhRMA

Worked examples

Example 1 — a first encounter with List of investigational sex-hormonal agents

Start with the simplest possible case. Write down what List of investigational sex-hormonal agents claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational sex-hormonal agents before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational sex-hormonal agents ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational sex-hormonal agents

In research: List of investigational sex-hormonal agents appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational sex-hormonal agents in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational sex-hormonal agents is common in secondary-school and first-year university syllabi. It links to neighbouring topics Experimental sex-hormone agents, Hormonal agents, Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational sex-hormonal agents outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study List of investigational sex-hormonal agents in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what List of investigational sex-hormonal agents means in your own words.
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Work through the three examples above with pen and paper.
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Frequently asked questions

What is List of investigational sex-hormonal agents in simple terms?

Why does List of investigational sex-hormonal agents matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study List of investigational sex-hormonal agents?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on List of investigational sex-hormonal agents.