science

List of investigational social anxiety disorder drugs

List of investigational social anxiety disorder drugs is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand List of investigational social anxiety disorder drugs rather than just read about it. In short: This is a list of investigational social anxiety disorder drugs, or drugs that are currently under development for clinical use in the treatment of social anxiety disorder (SAD; or social phobia) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

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Reference excerpt

This is a list of investigational social anxiety disorder drugs, or drugs that are currently under development for clinical use in the treatment of social anxiety disorder (SAD; or social phobia) but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. This list was last comprehensively updated in August 2024. It is likely to become outdated with time.

Under development

Phase 3 Fasedienol (Aloradine; AM-005; PH-94B; 4-androstadienol) – vomeropherine Soclenicant (BNC-210; IW-2143) – α7 nicotinic acetylcholine receptor negative allosteric modulator VQW-765 (VQW765; AQW051; AQW-051; JQH481R778) – α7 nicotinic acetylcholine receptor partial agonist [1]

Phase 2/3 Riluzole sublingual (BHV-0223; Nurtec) – complex mechanism of action or glutamatergic modulator

Phase 2 Cannabidiol (CBD; ATL5; RLS103) – cannabinoid receptor modulator and other actions Cannabidiol (CBD; Empower CBD) – cannabinoid receptor modulator and other actions ENX-102 (ENX102) — α2, α3, and α5 subunit-containing GABAA receptor positive allosteric modulator and nonbenzodiazepine FKW00GA (FKW-00GA; TGW-00AA; TGW00AA) – serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A receptor antagonist JNJ-42165279 (JNJ-5279) – fatty acid amide hydrolase (FAAH) inhibitor (R)-Midomafetamine ((R)-MDMA; R-MDMA; EMP-01) – serotonin, norepinephrine, and dopamine releasing agent, weak serotonin 5-HT2A, 5-HT2B, 5-HT2C receptor agonist, entactogen, and weak psychedelic hallucinogen Non-racemic MDMA (ALA-002; 70–80% (R)-MDMA, 20–30% (S)-MDMA) – serotonin, norepinephrine, and dopamine releasing agent, weak serotonin 5-HT2A, 5-HT2B, 5-HT2C receptor agonist, entactogen, and weak psychedelic hallucinogen NTX-1472 (RO-6953958) – vasopressin V1A receptor antagonist ONO-1110 – endocannabinoid synthesis regulator and indirect cannabinoid receptor modulator [2] [3] [4] Oxytocin (intranasal potentiated oxytocin; TI-001; TI-114; TNX-1900; TNX-2900) – oxytocin receptor agonist Vilazodone (Viibryd) – serotonin 5-HT1A receptor partial agonist and serotonin reuptake inhibitor

Phase 1 SNTX-2643 (SENS-01) – atypical serotonin reuptake inhibitor (SRI) (kanna-derived)

Preclinical Dimethyltryptamine (DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen EX-14280 – fatty acid amide hydrolase (FAAH) inhibitor EX-14663 – fatty acid amide hydrolase (FAAH) inhibitor PSYLO-3001 (Psylo-3001) – non-selective serotonin receptor agonist and psychedelic hallucinogen Research programme: CNS disorders and substance-related disorders therapeutics - Kinoxis Therapeutics — oxytocin receptor modulators

Phase unknown Fluvoxamine extended-release – selective serotonin reuptake inhibitor (SSRI) Venlafaxine controlled-release – serotonin–norepinephrine reuptake inhibitor (SNRI)

Not under development

No development reported Bupropion (Wellbutrin) – norepinephrine–dopamine reuptake inhibitor (NDRI) and nicotinic acetylcholine receptor negative allosteric modulator EX-597 (KDS-4103; ORG-231295; URB-597) – fatty acid amide hydrolase (FAAH) inhibitor Guanfacine extended-release (Connexyn; Intuniv; Intuniv XR; S-877503; SHP-503; SPD-503) – α2-adrenergic receptor agonist

Development discontinued AV-608 (CGP-60829; NK-608; NKP-608C; NKP608) – neurokinin NK1 receptor antagonist Cycloserine (D-cycloserine; TIK-101; TIK101) — NMDA receptor partial agonist Tradipitant (LY-686017; VLY-686) – neurokinin NK1 receptor antagonist Verucerfont (GSK-561679; NBI-77860) – corticotropin-releasing hormone receptor 1 (CRF1) antagonist

Formal development never or not yet started Small-molecule oxytocin receptor agonists (e.g., LIT-001, LIT-002) 15-Lipoxygenase (15-LOX; ALOX15) inhibitors (small-molecule indirect oxytocin-like drugs) (e.g., KNX-100 (SOC-1), KNX-101)

Clinically used drugs

Approved drugs

Selective serotonin reuptake inhibitors (SSRIs) Escitalopram (Lexapro; Cipralex) – selective serotonin reuptake inhibitor Fluvoxamine (Depromel; Luvox) – selective serotonin reuptake inhibitor Paroxetine (Dropax; Serestill; Paxil; Seroxat) – selective serotonin reuptake inhibitor Sertraline (Zoloft; Lustral) – selective serotonin reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) Venlafaxine (Dobupal; Effexor; Effexor XR; Elafax) – serotonin–norepinephrine reuptake inhibitor

Monoamine oxidase inhibitors (MAOIs) Moclobemide (Manerix) – reversible inhibitor of monoamine oxidase A (RIMA)

Off-label drugs Alcohol (over-the-counter self-medication) – GABAA receptor positive allosteric modulator Atypical antipsychotics (e.g., olanzapine, quetiapine) – monoamine receptor modulators Benzodiazepines (e.g., alprazolam, chlordiazepoxide, clonazepam, diazepam, lorazepam, oxazepam) – GABAA receptor positive allosteric modulators Beta blockers (e.g., atenolol, propranolol) – β-adrenergic receptor antagonists Bupropion (Wellbutrin) – norepinephrine–dopamine reuptake inhibitor (NDRI) and nicotinic acetylcholine receptor negative allosteric modulator Cannabidiol (CBD) – cannabinoid receptor modulator and other actions, found in cannabis Gabapentinoids (e.g., gabapentin, pregabalin) – α2δ subunit-containing voltage-dependent calcium channel blockers Monoamine oxidase inhibitors (MAOIs) (e.g., phenelzine, selegiline, tranylcypromine) NMDA receptor antagonists (e.g., ketamine) Other anticonvulsants (besides gabapentinoids) (e.g., topiramate, valproic acid, tiagabine) Psychostimulants (e.g., amphetamine, methylphenidate) Selective serotonin reuptake inhibitors (SSRIs) (non-licensed) (e.g., citalopram, fluoxetine) Serotonin–norepinephrine reuptake inhibitors (SNRIs) (non-licensed) (e.g., desvenlafaxine, duloxetine) Serotonin 5-HT1A receptor agonists (e.g., buspirone) Tricyclic antidepressants (TCAs) (e.g., clomipramine, imipramine)

See also List of investigational drugs List of investigational generalized anxiety disorder drugs List of investigational panic disorder drugs List of investigational post-traumatic stress disorder drugs List of investigational anxiety disorder drugs List of investigational autism and pervasive developmental disorder drugs List of investigational aggression drugs

References

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Worked examples

Example 1 — a first encounter with List of investigational social anxiety disorder drugs

Start with the simplest possible case. Write down what List of investigational social anxiety disorder drugs claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to List of investigational social anxiety disorder drugs before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about List of investigational social anxiety disorder drugs ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of List of investigational social anxiety disorder drugs

In research: List of investigational social anxiety disorder drugs appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses List of investigational social anxiety disorder drugs in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: List of investigational social anxiety disorder drugs is common in secondary-school and first-year university syllabi. It links to neighbouring topics Anxiety disorders, Experimental psychiatric drugs, Lists of investigational drugs, so understanding it makes those chapters shorter.
In everyday life: Look for List of investigational social anxiety disorder drugs outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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