This is a list of psychoactive drugs, or drugs that produce psychoactive effects. Psychoactive drugs can be broadly grouped into stimulants, depressants, and hallucinogens and entactogens, although not all psychoactive drugs fall neatly into these categories. Many psychoactive drugs are recreational drugs or drugs of misuse, with these drugs generally falling into the categories of euphoriants and hallucinogens.
Stimulants
Adenosine receptor antagonists (e.g., caffeine, theophylline, theobromine, paraxanthine, istradefylline) Catecholamine releasing agents (e.g., amphetamine, methamphetamine, lisdexamfetamine, MDMA, mephedrone, cathinone, ephedrine) Catecholamine reuptake inhibitors (e.g., methylphenidate, MDPV, cocaine, modafinil, bupropion, atomoxetine) GABAA receptor antagonists (e.g., pentylenetetrazol) Glycine receptor antagonists (e.g., strychnine) Histamine H3 receptor antagonists (e.g., pitolisant) Muscarinic acetylcholine receptor agonists (e.g., arecoline) Nicotinic acetylcholine receptor agonists (e.g., nicotine) Orexin receptor agonists (e.g., danavorexton, oveporexton)
Depressants
GABAA receptor agonists (e.g., muscimol, gaboxadol) GABAA receptor positive allosteric modulators Alcohols (e.g., ethanol, tert-amyl alcohol) Barbiturates (e.g., phenobarbital, pentobarbital, secobarbital, thiopental) Benzodiazepines (e.g., diazepam, clonazepam, alprazolam, lorazepam, triazolam, temazepam) Carbamates (e.g., meprobamate, carisoprodol) Inhalants/volatiles (e.g., chloral hydrate, chloroform, diethyl ether, halothane, sevoflurane) Neurosteroids (e.g., progesterone, allopregnanolone/brexanolone, zuranolone) Nonbenzodiazepines/Z drugs (e.g., zolpidem, zopiclone, eszopiclone, zaleplon) Quinazolinones (e.g., methaqualone) Others (e.g., etomidate, glutethimide, kava/kavalactones, potassium bromide, propofol) GABAB receptor agonists (e.g., GHB/sodium oxybate, GBL, 1,4-butanediol (1,4-BD), phenibut) Gabapentinoids (α2δ ligands) (e.g., gabapentin, pregabalin, gabapentin enacarbil, phenibut) Histamine H1 receptor antagonists (e.g., diphenhydramine, doxylamine, hydroxyzine, doxepin, mirtazapine) Melatonin receptor agonists (e.g., melatonin, ramelteon, tasimelteon) Opioids (μ-opioid receptor agonists) (e.g., codeine, morphine, heroin, hydrocodone, oxycodone, fentanyl, methadone, buprenorphine, kratom) Orexin receptor antagonists (e.g., suvorexant, lemborexant, daridorexant, seltorexant)
Hallucinogens
Psychedelics (serotonin 5-HT2A receptor agonists) (e.g., LSD, psilocybin, mescaline, dimethyltryptamine (DMT), 5-MeO-DMT, 2C-B, ergine) Dissociatives (NMDA receptor antagonists) (e.g., ketamine, phencyclidine (PCP), dextromethorphan (DXM), nitrous oxide (N2O)) Deliriants (muscarinic acetylcholine receptor antagonists) (e.g., scopolamine, atropine, hyoscyamine, diphenhydramine, trihexyphenidyl) Oneirogens (e.g., ibogaine, harmaline, tetrahydroharmine (THH)) GABAA receptor agonists (e.g., muscimol, gaboxadol) κ-Opioid receptor agonists (e.g., salvinorin A, pentazocine) Cannabinoids (cannabinoid CB1 receptor agonists) (e.g., tetrahydrocannabinol (THC), nabilone, JWH-018, JWH-073, HU-210) Others (e.g., carbogen, hallucinogenic bolete mushrooms/Lanmaoa asiatica, hallucinogenic fish/ichthyoallyeinotoxism, mad honey, nutmeg)
Others Cannabinoids (cannabinoid CB1 receptor agonists) (e.g., tetrahydrocannabinol (THC), nabilone, JWH-018, JWH-073, HU-210) Entactogens (serotonin releasing agents) (e.g., MDMA, MDA, methylone, mephedrone, 5-MAPB, 6-APB, MDAI, Borax combo) Glucocorticoids (glucocorticoid receptor agonists) (e.g., cortisol/hydrocortisone, prednisone, prednisolone, dexamethasone) Nootropics (e.g., piracetam) Poppers/alkyl nitrites (e.g., amyl nitrite) Others (e.g., blue lotus/blue water lily, brivaracetam, flupirtine, kanna, lacosamide, lasmiditan, perampanel, retigabine (ezogabine), etc.)
Psychiatric drugs
Antidepressants (e.g., SSRIs, SNRIs, TCAs, TeCAs, SARIs, MAOIs, bupropion) Antipsychotics (e.g., typical antipsychotics like chlorpromazine and haloperidol and atypical antipsychotics like quetiapine and aripiprazole) Anxiolytics (e.g., azapirones like buspirone and tandospirone, beta blockers like propranolol, etc.) Mood stabilizers (e.g., lithium, valproic acid, carbamazepine, lamotrigine)
See also Recreational drug use List of drugs List of designer drugs List of euphoriants List of psychoactive plants List of psychiatric drugs by type List of substances used in rituals Psychonautics
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