Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a protein that in humans is encoded by the LRP4 gene. LRP-4 is a member of the Lipoprotein receptor-related protein family and may be a regulator of Wnt signaling.
Clinical significance Mutations in this gene are associated with Cenani Lenz syndactylism. Autoantibodies against LRP4 have been connected to and diagnostic for a small fraction (i.e., less than 1%) of myasthenia gravis cases.
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