Low birth weight (LBW) is defined by the World Health Organization as a birth weight of an infant of 2,499 g (5 lb 8.1 oz) or less, regardless of gestational age. LBW can be caused from a variety of things such as the infant simply being born at a low gestational weight (ie. preterm), environmental factors, or the health of the infant's mother while pregnant. Low birth weight has been associated with higher rates of maternal discrimination, stress and poor prenatal healthcare access. Infants born with LBW have added health risks which require close management, often in a neonatal intensive care unit (NICU). Management of LBW includes temperature regulation, fluid balance, nutrition and sometimes hematology. They are also at increased risk for long-term health conditions which require follow-up over time. Low birth weight is associated with increased infant death in the weeks following birth as well as neurodevelopmental disorders. It is a global initiative to decrease LBW prevalence, especially in highly affected populations in South Asia and Sub Saharan Africa.
Classification Birth weight is defined as the weight an infant weighs at or around the time of birth, ideally the first weight measured within the first few hours postnatal. Birth weight may be classified as:
High birth weight (macrosomia): greater than 4,200 g (9 lb 4 oz) Normal weight (term delivery): 2,500–4,200 g (5 lb 8 oz – 9 lb 4 oz) Low birth weight: less than 2,500 g (5 lb 8 oz) Very low birth weight (VLBW): less than 1,500 g (3 lb 5 oz) Extremely low birth weight: less than 1,000 g (2 lb 3 oz)
Causes LBW is either caused by preterm birth (that is, a low gestational age at birth, commonly defined as younger than 37 weeks of gestation) or the infant being small for gestational age (that is, a slow prenatal growth rate), or a combination of both. In general, risk factors in the mother that may contribute to low birth weight include young ages, multiple pregnancies, previous LBW infants, poor nutrition, heart disease or hypertension, untreated celiac disease, substance use disorder, excessive alcohol use, and insufficient prenatal care. It can also be caused by prelabor rupture of membranes. Environmental risk factors include smoking, lead exposure, and other types of air pollution.
Preterm birth
Preterm birth could be spontaneous or medically-indicated in the form of prescribed cesarean sections to avoid complications from conditions such as pre-eclampsia. The mechanism of spontaneous preterm birth is heterogeneous and poorly understood. It may be tied to one or more of the following processes: premature fetal endocrine activation, intrauterine inflammation, over-distension of the uterus, and endometrial bleeding. A prominent risk factor for preterm birth is prior history of preterm delivery. However, there is no reliable protocol for screening and prevention of preterm birth.
Small for gestational age
Infants born small for gestational age may be constitutionally small, with no associated pathologic process. Others have intrauterine growth restriction (IUGR) due to any of various pathologic processes. Babies with chromosomal abnormalities or other congenital anomalies may manifest IUGR as part of their syndrome. Problems with the placenta can prevent it from providing adequate oxygen and nutrients to the fetus, resulting in growth restriction. Two significant placental pathologies include placental abruption and placental praevia. Infections during pregnancy that affect the fetus, such as rubella, cytomegalovirus, toxoplasmosis, and syphilis, may also affect the baby's weight.
Environmental factors
Maternal tobacco smoking doubles risk of LBW for the infant. More recently, passive maternal smoking, commonly referred to as second hand smoke, has been examined for possible effects on birth weight, and has been shown to increase risk of LBW by 16%.
Air pollutants The combustion products of solid fuel in developing countries can cause many adverse health issues in people. Because a majority of pregnant women in developing countries, where rate of LBW is high, are heavily exposed to indoor air pollution, increased relative risk translates into substantial population attributable risk of 21% of LBW. Particulate matter, a component of ambient air pollution, is associated with increased risk of low birth weight. Because particulate matter is composed of extremely small particles, even nonvisible levels can be inhaled and present harm to the fetus. Particulate matter exposure can cause inflammation, oxidative stress, endocrine disruption, and impaired oxygen transport access to the placenta, all of which are mechanisms for heightening the risk of low birth weight. To reduce exposure to particulate matter, pregnant women can monitor the US Environmental Protection Agency's air quality index and take personal precautionary measures such as reducing outdoor activity on low quality days, avoiding high-traffic roads/intersections, and/or wearing personal protective equipment (i.e., facial mask of industrial design). Indoor exposure to particulate matter can also be reduced through adequate ventilation, as well as use of clean heating and cooking methods. A correlation between maternal exposure to carbon monoxide (CO) and low birth weight has been reported that the effect on birth weight of increased ambient CO was as large as the effect of the mother smoking a pack of cigarettes per day during pregnancy. It has been revealed that adverse reproductive effects (e.g., risk for LBW) were correlated with maternal exposure to CO emissions in Eastern Europe and North America. Mercury is a known toxic heavy metal that can harm fetal growth and health, and there has been evidence showing that exposure to mercury (via consumption of large oily fish) during pregnancy may be related to higher risks of LBW in the offspring.
Other exposures Elevated blood lead levels in pregnant women, even those well below the US Centers for Disease Control and Prevention's 10 ug/dL "level of concern", can cause miscarriage, premature birth, and LBW in the offspring. Exposure of pregnant women to airplane noise was found to be associated with low birth weight via adverse effects on fetal growth. Prevalence of low birth weight in Japan is associated with radiation doses from the Fukushima accidents of March 2011.
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