chemistry

Lu 38-012

Lu 38-012 is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Lu 38-012 rather than just read about it. In short: Lu 38-012 is a potent and selective dopamine D4 receptor antagonist which has been used in scientific research. It has an affinity (Ki) for the dopamine D4.2 receptor of 7.5 nM and showed 16-fold selectivity for this receptor over the dopamine D2S receptor (Ki = 120 nM).

Key takeaways

Lu 38-012 belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Lu 38-012 to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Lu 38-012 from memory before moving on to harder problems.

Reference excerpt

Lu 38-012 is a potent and selective dopamine D4 receptor antagonist which has been used in scientific research. It has an affinity (Ki) for the dopamine D4.2 receptor of 7.5 nM and showed 16-fold selectivity for this receptor over the dopamine D2S receptor (Ki = 120 nM). The drug had relatively little affinity for other dopamine receptors. Affinities at other targets have also been reported. The drug produces hypolocomotion and reverses dextroamphetamine- and phencyclidine (PCP)-induced hyperlocomotion without producing catalepsy in rodents. Lu 38-012 partially substituted for clozapine in drug discrimination tests in rodents. It was developed by Lundbeck and was first described in the scientific literature by 2006.

See also Substituted phenylpiperazine Lu 35-138 Sonepiprazole

References

Illustrations

Worked examples

Example 1 — a first encounter with Lu 38-012

Start with the simplest possible case. Write down what Lu 38-012 claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Lu 38-012 before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Lu 38-012 ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Lu 38-012

In research: Lu 38-012 appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Lu 38-012 in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Lu 38-012 is common in secondary-school and first-year university syllabi. It links to neighbouring topics 4-Chlorophenyl compounds, D2 antagonists, D4 antagonists, so understanding it makes those chapters shorter.
In everyday life: Look for Lu 38-012 outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Lu 38-012 in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Lu 38-012 means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Lu 38-012 out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Lu 38-012 in simple terms?

Why does Lu 38-012 matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Lu 38-012?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Lu 38-012.