biology

Lydia W. S. Finley

Lydia W. S. Finley is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Lydia W. S. Finley rather than just read about it. In short: Lydia W. S.

Key takeaways

Lydia W. S. Finley belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Lydia W. S. Finley to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Lydia W. S. Finley from memory before moving on to harder problems.

Reference excerpt

Lydia W. S. Finley is an American scientist and an assistant member at the Cell Biology Program at Memorial Sloan Kettering Cancer Center and an assistant professor at Weill Cornell Medical College. Finley is known for her contributions to understanding the metabolic underpinnings of stem cell fate.

Biography Finley received her Bachelor of Science (BS) degree summa cum laude from Yale University. Finley completed her PhD at Harvard Medical School, where she worked in the laboratory of Marcia Haigis. Finley then worked as a postdoctoral fellow in the laboratory of Craig Thompson at Memorial Sloan Kettering Cancer Center. After completing her postdoctoral work, Finley opened her own laboratory in 2017, which is located in the Memorial Sloan Kettering Cancer Center. Finley has received various awards for her work. These include the Dale F. Frey Award for Breakthrough Scientists from the Damon Runyon Cancer Research Foundation and the Searle Scholars Award. Finley currently serves as an associate editor for Cancer & Metabolism and a reviewing editor at eLife. As of April 2022, Finley has authored over 40 publications and has an h-index of 30.

Scientific contributions Finley's research has focused on interrogating the connections between metabolites and their role in regulating embryonic stem cell self-renewal and cell fate decisions. Notably, as a postdoctoral fellow, Finley and Bryce W. Carey discovered that intracellular α-ketoglutarate levels regulated chromatin and gene expression, and contributes to embryonic stem cell renewal. In 2022, Finley and co-authors published a paper describing a non-canonical arm of the TCA cycle.

Selected awards and honors National Science Foundation Graduate Research Fellowship Dale F. Frey Award for Breakthrough Scientists, Damon Runyon Cancer Research Foundation 2018: Searle Scholar 2020: Pershing Square Sohn Cancer Research Alliance Award

Selected publications Carey BW*, Finley LW*, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518(7539):413-416. doi:10.1038/nature13981 Arnold, PK; Jackson, BT; Paras, KI; Brunner, JS; Hart, ML; Newsom, OJ; Alibeckoff, SP; Endress, J; Drill, E; Sullivan, LB; Finley, LWS (2022). "A non-canonical tricarboxylic acid cycle underlies cellular identity". Nature. 603 (7901): 477–481. Bibcode:2022Natur.603..477A. doi:10.1038/s41586-022-04475-w. PMC 8934290. PMID 35264789.

References

Worked examples

Example 1 — a first encounter with Lydia W. S. Finley

Start with the simplest possible case. Write down what Lydia W. S. Finley claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Lydia W. S. Finley before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Lydia W. S. Finley ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Lydia W. S. Finley

In research: Lydia W. S. Finley appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Lydia W. S. Finley in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Lydia W. S. Finley is common in secondary-school and first-year university syllabi. It links to neighbouring topics 21st-century American biologists, 21st-century American women biologists, American cell biologists, so understanding it makes those chapters shorter.
In everyday life: Look for Lydia W. S. Finley outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Lydia W. S. Finley in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Lydia W. S. Finley means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Lydia W. S. Finley out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Lydia W. S. Finley in simple terms?

Lydia W. S.

Why does Lydia W. S. Finley matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Lydia W. S. Finley?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Lydia W. S. Finley.