chemistry

Lysergic acid propylamide

Lysergic acid propylamide is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Lysergic acid propylamide rather than just read about it. In short: Lysergic acid propylamide (LAP), also known as N-propyllysergamide (NP-LA), is a serotonin receptor modulator of the lysergamide family related to the psychedelic drug lysergic acid diethylamide (LSD). It is the analogue of LSD in which the N,N-diethyl groups have been replaced with an N-propyl group and is also the N-propyl derivative of ergine (lysergic acid amide; LSA).

Key takeaways

Lysergic acid propylamide belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Lysergic acid propylamide to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Lysergic acid propylamide from memory before moving on to harder problems.

Reference excerpt

Lysergic acid propylamide (LAP), also known as N-propyllysergamide (NP-LA), is a serotonin receptor modulator of the lysergamide family related to the psychedelic drug lysergic acid diethylamide (LSD). It is the analogue of LSD in which the N,N-diethyl groups have been replaced with an N-propyl group and is also the N-propyl derivative of ergine (lysergic acid amide; LSA).

Use and effects It was initially reported that LAP was inactive as a hallucinogen in humans but produced autonomic effects at relatively low doses in both animals and humans, with no other details, such as doses, provided. Subsequently, Alexander Shulgin reported that LAP was inactive at a psychedelic at doses of up to 500 μg and had at least less than 20% of the hallucinogenic potency of LSD.

Pharmacology The drug had about 40% of the antiserotonergic activity of LSD in the isolated rat uterus in vitro. The potency of LSD analogues in this assay increased with length or size of the monoalkyl chain: ergine (4.3%) < lysergic acid methylamide (6.3%) < lysergic acid ethylamide (11.9%) < lysergic acid isopropylamide (22.2%) < LAP (40.0%) < lysergic acid butylamide (64.9%) < lysergic acid amylamide (75.1%). However, activity in this assay does not correlate with hallucinogenic activity.

History LAP was first described in the scientific literature by Albert Hofmann and colleagues by 1955.

See also Substituted lysergamide Lysergic acid methylamide (LAM) Lysergic acid ethylamide (LAE-32 or LAE) Lysergic acid butylamide (LAB) Lysergic acid amylamide Lysergic acid dipropylamide (LSDP)

References

External links NP-LA - Isomer Design

Illustrations

Worked examples

Example 1 — a first encounter with Lysergic acid propylamide

Start with the simplest possible case. Write down what Lysergic acid propylamide claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Lysergic acid propylamide before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Lysergic acid propylamide ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Lysergic acid propylamide

In research: Lysergic acid propylamide appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Lysergic acid propylamide in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Lysergic acid propylamide is common in secondary-school and first-year university syllabi. It links to neighbouring topics Carboxamides, Drugs not assigned an ATC code, Lysergamides, so understanding it makes those chapters shorter.
In everyday life: Look for Lysergic acid propylamide outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Lysergic acid propylamide in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Lysergic acid propylamide means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Lysergic acid propylamide out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Lysergic acid propylamide in simple terms?

Why does Lysergic acid propylamide matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Lysergic acid propylamide?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Lysergic acid propylamide.