Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily. The Y-chromosome version of this gene is called UTY.
Function UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene derepression, a potential means of regulating cellular metabolism.
See also Demethylase Demethylation Dioxygenase Histone Histone H3 Lysine 2-Oxoglutarate Tetratricopeptide repeat
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