Lysophosphatidylinositol (LPI, lysoPI), or L-α-lysophosphatidylinositol, is an endogenous lysophospholipid and endocannabinoid neurotransmitter. LPI, along with its 2-arachidonoyl- derivative, 2-arachidonoyl lysophosphatidylinositol (2-ALPI), have been proposed as the endogenous ligands of GPR55. Recent studies have shown that the fatty acyl composition of LPI influences neuroinflammatory responses in primary neuronal cultures, highlighting its potential role in neuroinflammation.
See also Phosphatidylinositol Cannabinoid receptor
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