MAG1 is a gene in the yeast Saccharomyces cerevisiae that encodes DNA-3-methyladenine glycosylase, a monofunctional DNA N-glycosylase involved in base excision repair. It initiates repair of alkylation damage and helps protect yeast cells from methylating agents.
Function MAG1 transcription is induced when yeast cells are exposed to relatively non-toxic levels of alkylating agents. The encoded glycosylase has been reported to excise 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine from DNA.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
