ArticleslgStudy

chemistry

MANET database

MANET database is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand MANET database rather than just read about it. In short: The Molecular Ancestry Network (MANET) database is a bioinformatics database that maps evolutionary relationships of protein architectures directly onto biological networks. It was originally developed by Hee Shin Kim, Jay E.

MANET database — main illustration
MANET database — illustration

Key takeaways

  • MANET database belongs to chemistry; place it in that map before memorising details.
  • Learn the definition first, then one example that makes the definition concrete.
  • Connect MANET database to a quantity you can measure, compute or draw — that is where exam questions come from.
  • Reproduce the core statement of MANET database from memory before moving on to harder problems.

Reference excerpt

The Molecular Ancestry Network (MANET) database is a bioinformatics database that maps evolutionary relationships of protein architectures directly onto biological networks. It was originally developed by Hee Shin Kim, Jay E. Mittenthal and Gustavo Caetano-Anollés in the Department of Crop Sciences of the University of Illinois at Urbana-Champaign. MANET traces for example the ancestry of individual metabolic enzymes in metabolism with bioinformatic, phylogenetic, and statistical methods. MANET currently links information in the Structural Classification of Proteins (SCOP) database, the metabolic pathways database of the Kyoto Encyclopedia of Genes and Genomes (KEGG), and phylogenetic reconstructions describing the evolution of protein fold architecture at a universal level. The database has been updated to reflect the evolution of metabolism at the level of protein fold families. MANET literally "paints" the ancestries of enzymes derived from rooted phylogenetic trees directly onto over one hundred metabolic pathways representations, paying homage to one of the fathers of impressionism. It also provides numerous functionalities that enable searching specific protein folds with defined ancestry values, displaying the distribution of enzymes that are painted, and exploring quantitative details describing individual protein folds. This permits the study of global and local metabolic network architectures, and the extraction of evolutionary patterns at global and local levels. The database is useful for the study of metabolic evolution. A statistical analysis of the data in MANET showed for example a patchy distribution of ancestry values assigned to protein folds in each subnetwork, indicating that evolution of metabolism occurred globally by widespread recruitment of enzymes. MANET was used to sort out enzymatic recruitment processes in metabolic networks and propose that modern metabolism originated in the purine nucleotide metabolic subnetwork. Analysis of the purine metabolism revealed gradual evolutionary replacement of abiotic chemistries by protein enzymes. The database helped uncover a physical and evolutionary conservation trace in the structure of active sites during the emergence of metabolic activities.

External links Molecular Ancestry Network (MANET) database Web archive

References

Illustrations

MANET database: A collage of the 148 subnetwork diagrams of MANET 3.0 (in the top) and the oldest subnetwork, NUC00230 purine metabolism (in the bottom), highlight how metabolic pathways are enzymatic patchworks of different evolutionary ages.[1]
A collage of the 148 subnetwork diagrams of MANET 3.0 (in the top) and the oldest subnetwork, NUC00230 purine metabolism (in the bottom), highlight how metabolic pathways are enzymatic patchworks of different evolutionary ages.[1]

Worked examples

Example 1 — a first encounter with MANET database

Start with the simplest possible case. Write down what MANET database claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to MANET database before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about MANET database ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of MANET database

In research
MANET database appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry
Engineering practice reuses MANET database in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom
MANET database is common in secondary-school and first-year university syllabi. It links to neighbouring topics Biochemistry databases, Metabolomic databases, so understanding it makes those chapters shorter.
In everyday life
Look for MANET database outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study MANET database in 20 minutes

  1. Read the reference excerpt below once, without taking notes.
  2. Close the page and write down what MANET database means in your own words.
  3. Compare your version with the excerpt and mark what you missed.
  4. Work through the three examples above with pen and paper.
  5. Explain MANET database out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is MANET database in simple terms?

The Molecular Ancestry Network (MANET) database is a bioinformatics database that maps evolutionary relationships of protein architectures directly onto biological networks. It was originally developed by Hee Shin Kim, Jay E.

Why does MANET database matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study MANET database?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on MANET database.

Tags

  • Biochemistry databases
  • Metabolomic databases

Keep exploring