Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. MAP4Ks are involved in regulating cellular processes, including proliferation, differentiation, migration, and apoptosis. There are currently seven identified MAP4Ks.
MAP4K1 (aka HPK1) MAP4K2 (aka GCK) MAP4K3 (aka GLK) - plays a role in TCR mediated immune responses and cell signaling. MAP4K4 (aka HGK) - involved in cell proliferation and migration. MAP4K5 (aka KHS) MAP4K6 (aka MINK) - poorly described enzyme that has been linked to hepatocellular carcinoma (HCC). MAP4K7 (aka TNIK)
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See also Signal transduction MAP kinase MAP kinase kinase MAP kinase kinase kinase List of unusual biological names
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