Macluraxanthone is a naturally occurring organic compound with the formula C23H22O6. Belonging to the xanthone family, it is a trihydroxylated xanthone characterized by the presence of a pyran ring and a prenyl chain. Its structure features a catechol moiety, a xanthene core, and a chromene ring. Acetylation of macluraxanthone yields a triacetate derivative with the formula C29H28O9. X-ray crystallography of a synthesized derivative (Di-p-bromobenzenesulfonyl-macluraxanthone) reveals a planar xanthene ring system and a screw boat conformation in the chromene ring. Macluraxanthone has demonstrated antimalarial and larvicidal activity, including effects against Plasmodium falciparum and vector mosquito larvae. Additional studies have reported antibacterial activity against Enterococcus faecalis.
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