biology

Maddika Subba Reddy

Maddika Subba Reddy is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Maddika Subba Reddy rather than just read about it. In short: Maddika Subba Reddy is an Indian cell biologist and the head of the Laboratory of Cell Death and Cell Survival (LCDCS) of the Centre for DNA Fingerprinting and Diagnostics. A Wellcome-DBT Senior Fellow, Reddy is known for his studies cell signaling and phosphatases.

Key takeaways

Maddika Subba Reddy belongs to biology; place it in that map before memorising details.
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Reference excerpt

Maddika Subba Reddy is an Indian cell biologist and the head of the Laboratory of Cell Death and Cell Survival (LCDCS) of the Centre for DNA Fingerprinting and Diagnostics. A Wellcome-DBT Senior Fellow, Reddy is known for his studies cell signaling and phosphatases. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18.

Biography

Maddika Subba Reddy secured his PhD in Biochemistry and Medical Genetics from the University of Manitoba in 2007. His post-doctoral training was at the laboratory of Junjie Chen of Yale University and on his return to India in 2009, he joined the Centre for DNA Fingerprinting and Diagnostics (CDFD) where he heads the Laboratory of Cell Death and Cell Survival (LCDCS). A Wellcome Trust-DBT India Alliance senior fellow since 2016, Reddy is known for his studies on cellular phosphatases and cellular signaling pathways. The team led by Reddy is credited with the identification of NEDD4-like E3 ubiquitin-protein ligase WWP2, an E3 ligase, as a regulator for PTEN, a tumor suppressor gene and the discovery is reported to have significance in controlling cell proliferation, thereby in controlling cancer. He has published a number of articles; ResearchGate, an online repository of scientific articles has listed 77 of them.

Awards and honors The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards, for his contributions to biosciences, in 2017/18. An elected member of the Guha Research Conference and a former young associate of the Indian Academy of Sciences, he is also a recipient of the NASI-Scopus Young Scientist Award of the Elsevier and National Academy of Sciences, India for the year 2017.

Selected bibliography Maddika, Subbareddy; Gangula, Narmadha Reddy (2017-08-25). "Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1". Journal of Biological Chemistry. 292 (34): 13947–13958. doi:10.1074/jbc.M117.782896. ISSN 1083-351X. PMC 5572923. PMID 28696259. Maddika, Subbareddy; Gangula, Narmadha Reddy (2013-11-29). "WD Repeat Protein WDR48 in Complex with Deubiquitinase USP12 Suppresses Akt-dependent Cell Survival Signaling by Stabilizing PH Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1)". Journal of Biological Chemistry. 288 (48): 34545–34554. doi:10.1074/jbc.M113.503383. ISSN 1083-351X. PMC 3843068. PMID 24145035. Maddika, Subbareddy; Shinde, Swapnil Rohidas (2016-02-12). "PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7". Nature Communications. 7 10689. Bibcode:2016NatCo...710689S. doi:10.1038/ncomms10689. ISSN 2041-1723. PMC 4754336. PMID 26869029. Los, Marek; Ghavami, Saeid; Gibson, Spencer B.; Johar, Dina; Booy, Evan P.; Maddika, Subbareddy (2005-10-01). "Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway". Journal of Cell Science. 118 (19): 4485–4493. doi:10.1242/jcs.02580. ISSN 1477-9137. PMID 16179607. Maddika, Subbareddy; Chen, Junjie; Srinivasulu, Mukta; Sastry, Regulagadda A.; Rao, Subramanyeshwar; Pattnaik, Sujit; Vamsy, Mohana; Gowrishankar, Swarnalata; Bashyam, Murali D. (2013-01-01). "PNUTS Functions as a Proto-Oncogene by Sequestering PTEN". Cancer Research. 73 (1): 205–214. doi:10.1158/0008-5472.CAN-12-1394. ISSN 1538-7445. PMC 3538077. PMID 23117887.

Illustrations

Maddika Subba Reddy: Phosphatase and tensin homolog (PTEN) — Phosphatase and tensin homolog (PTEN)

Worked examples

Example 1 — a first encounter with Maddika Subba Reddy

Start with the simplest possible case. Write down what Maddika Subba Reddy claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Maddika Subba Reddy before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Maddika Subba Reddy ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Maddika Subba Reddy

In research: Maddika Subba Reddy appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Maddika Subba Reddy in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Maddika Subba Reddy is common in secondary-school and first-year university syllabi. It links to neighbouring topics Indian cell biologists, Living people, N-BIOS Prize recipients, so understanding it makes those chapters shorter.
In everyday life: Look for Maddika Subba Reddy outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Maddika Subba Reddy in 20 minutes

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Close the page and write down what Maddika Subba Reddy means in your own words.
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Frequently asked questions

What is Maddika Subba Reddy in simple terms?

Why does Maddika Subba Reddy matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Maddika Subba Reddy?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Maddika Subba Reddy.