biology

Madhusoodan V. Hosur

Madhusoodan V. Hosur is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Madhusoodan V. Hosur rather than just read about it. In short: Madhusoodan Vijayacharya Hosur (born 24 December 1950) also known as MV Hosur is an Indian structural biologist and crystallographer known for his work on macromolecular crystallography, including viral and HIV-1 protease structures, and for contributions to drug-design research. Early life and education He received his Ph.D. in X-ray crystallography of nucleotides, coenzymes and high-energy phosphates from the Indi…

Key takeaways

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Reference excerpt

Madhusoodan Vijayacharya Hosur (born 24 December 1950) also known as MV Hosur is an Indian structural biologist and crystallographer known for his work on macromolecular crystallography, including viral and HIV-1 protease structures, and for contributions to drug-design research.

Early life and education He received his Ph.D. in X-ray crystallography of nucleotides, coenzymes and high-energy phosphates from the Indian Institute of Science (IISc), Bengaluru, India during (1973–1979). He then carried out early work as a Research Associate, University of Wisconsin–Madison (1979–1981), on the X-ray crystallography of oligonucleotides. Later he worked at the Purdue University (1982–1986) on the X-ray structure of spherical viruses.

Career He joined BARC, Mumbai, as Scientific Officer in 1986 and stayed there until 1999 on the work related to macromolecular crystallography and drug‐design. From 1999 to 2012, he was with the Protein Crystallography Section, Solid-State Physics Division (SSPD) at BARC as head. His work was focused on viral protein structures, malaria proteins, and drug-resistance mechanisms. Later he moved to the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) in Navi Mumbai, continuing his research in biophysics, crystallography, and big-data epilepsy from 2013 to 2016. From 2017 onward, he has been an INSA-Senior scientist and holding adjunct professorship at the National Institute of Advanced Studies, Bangalore. He focuses on big-data approaches in epilepsy and other biomedical fields.

Awards and honours Fellow of the Indian National Science Academy (INSA) (2010) Wenner‑Gren Visiting Fellowship at Lund University (2001) Martin‐Forster Gold Medal from Indian Institute of Science (1979)

Selected Bibliography Chaudhuri, T; Hosur, MV (2024). "Molecular modelling reveals how abundance of α4 sub-type in synaptic GABAR(A) receptor can lead to refractoriness toward GABA and BZ-type drugs". Journal of Biomolecular Structure & Dynamics. 42 (24): 13680–13687. doi:10.1080/07391102.2023.2277858. PMID 37948195. Chaudhuri, T; Chintalapati, J; Hosur, MV (2021). "Identification of 3'-UTR single nucleotide variants and prediction of select protein imbalance in mesial temporal lobe epilepsy patients". PLOS ONE. 16 (6) e0252475. Bibcode:2021PLoSO..1652475C. doi:10.1371/journal.pone.0252475. PMC 8177469. PMID 34086756. Prashar, V; Bihani, SC; Ferrer, JL; Hosur, MV (September 2015). "Structural Basis of Why Nelfinavir-Resistant D30N Mutant of HIV-1 Protease Remains Susceptible to Saquinavir". Chemical Biology & Drug Design. 86 (3): 302–8. doi:10.1111/cbdd.12494. PMID 25487655. Bihani, S; Das, A; Prashar, V; Ferrer, JL; Hosur, MV (15 February 2009). "X-ray structure of HIV-1 protease in situ product complex". Proteins. 74 (3): 594–602. doi:10.1002/prot.22174. PMID 18704947. Prashar, V; Hosur, MV (29 October 2004). "1.8A X-ray structure of C95M/C1095F double mutant of tethered HIV-1 protease dimer complexed with acetyl pepstatin". Biochemical and Biophysical Research Communications. 323 (4): 1229–35. Bibcode:2004BBRC..323.1229P. doi:10.1016/j.bbrc.2004.08.226. PMID 15451428. Hosur, MV; Sainis, JK; Kannan, KK (20 December 1993). "Crystallization and X-ray analysis of a multienzyme complex containing RUBISCO and RuBP". Journal of Molecular Biology. 234 (4): 1274–8. doi:10.1006/jmbi.1993.1681. PMID 8263930. Hosur, MV; Schmidt, T; Tucker, RC; Johnson, JE; Gallagher, TM; Selling, BH; Rueckert, RR (1987). "Structure of an insect virus at 3.0 A resolution". Proteins. 2 (3): 167–76. doi:10.1002/prot.340020302. PMID 3447176.

References

Illustrations

Worked examples

Example 1 — a first encounter with Madhusoodan V. Hosur

Start with the simplest possible case. Write down what Madhusoodan V. Hosur claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Madhusoodan V. Hosur before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Madhusoodan V. Hosur ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Madhusoodan V. Hosur

In research: Madhusoodan V. Hosur appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Madhusoodan V. Hosur in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Madhusoodan V. Hosur is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1950 births, Fellows of the Indian National Science Academy, Indian Institute of Science alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Madhusoodan V. Hosur outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

What is Madhusoodan V. Hosur in simple terms?

Why does Madhusoodan V. Hosur matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Madhusoodan V. Hosur?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Madhusoodan V. Hosur.