biology

Magdalena Götz

Magdalena Götz is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Magdalena Götz rather than just read about it. In short: Magdalena Götz (born 17 January 1962) is a German neuroscientist. She is noted for her study of glial cells and holds a chair at LMU Munich's Department of Physiology.

Key takeaways

Magdalena Götz belongs to biology; place it in that map before memorising details.
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Reproduce the core statement of Magdalena Götz from memory before moving on to harder problems.

Reference excerpt

Magdalena Götz (born 17 January 1962) is a German neuroscientist. She is noted for her study of glial cells and holds a chair at LMU Munich's Department of Physiology. She is involved in the field of adult neurogenesis. Götz discovered that glial cells are neural stem cells in the developing mammalian brain. Current investigations study the mechanisms involved in determining how adult neural stem cells are specified. Götz current work focuses on refining ways to reprogram glial cells into neurons in organisms with traumatic brain injury. The German Stem Cell Network published an interview with Götz in 2015 explaining her research field.

Early life and education Götz studied Biology between the years 1982 and 1989 at the University of Tübingen, Germany and in Zürich, Switzerland. She was promoted in 1992 to the position of Dr. rer. nat. at the Friedrich-Miescher Laboratory of the Max-Planck Society, Tübingen. After her promotion and until 1996, she was a postdoctoral fellow at the National Institute for Medical Research, London and Smith Kline Beecham, Harlow.

Career Götz led an independent Research Group at the Max-Planck Institute of Neurobiology in Martinsried, Munich between 1997 and 2003. She has been the Director of the Institute of Stem Cell Research at the Helmholtz Center Munich since 2004. Götz has been chair of Physiological Genomics at LMU Munich. Since 2011, Götz has held a Research Professorship at LMU. Götz is a member of the Synergy Board as well as a Principal Investigator in the Münch Cluster for Systems Neurology, also known as Synergy.

Awards and honors 2007 Gottfried Wilhelm Leibniz Prize 2007 Hansen Family Award 2008 Hans and Ilse Breuer Award 2010 Order of Merit of the Federal Republic of Germany 2013 Remedios Caro Almela Prize on Developmental Neurobiology 2014 Ernst Schering Prize 2014 Advanced Research Grant by the European Research Council (ERC) 2015 Carl-Zeiss Award of the German Society for Cell Biology 2015 German Stem Cell Network Female Scientist Award 2016 Prize of the Roger de Spoelberch Foundation 2018 Schellenberg Award

Publications Access the complete list of Götz's publications here.

Falkner S*, Grade S*, Dimou L, Conzelmann K-K, Bonhoeffer T, Götz M*, Hübener M*. Transplanted embryonic neurons integrate into adult neocortical circuits. Nature 539:248-53 (2016) Gascón S*, Murenu E*, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Robertson SP, Schroeder T, Beckers J, Irmler M, Berndt C, Angeli JP, Conrad M, Berninger B, Götz M. Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming. Cell Stem Cell 18:396-409 (2016) Masserdotti G*, Gillotin S*, Sutor B, Drechsel D, Irmler M, Jørgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, Guillemot F*, Götz M*. Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes. Cell Stem Cell 17:74-88 (2015) Ninkovic J, Steiner-Mezzadri A, Jawerka M, Akinci U, Masserdotti G, Petricca S, Fischer J, von Holst A, Beckers J, Lie CD, Petrik D, Miller E, Tang J, Wu J, Lefebvre V, Demmers J, Eisch A, Mezger D, Crabtree G, Irmler M, Poot R, Götz M. The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network. Cell Stem Cell 13:403-18 (2013) Stahl R, Walcher T, De Juan Romeo C, Pilz GA, Cappello S, Irmler M, Sanz Anquela JM, Beckers J, Blum R, Borrell V, Götz M. Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate. Cell 153:535-49 (2013) Sirko S*, Behrendt G*, Johansson P, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai L-H, Fischer A, Grobe K, Dimou L, Götz M. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. Cell Stem Cell 12:426-39 (2013) Bardehle S, Krüger M, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Buggenthin F, Theis FJ, Meyer-Luehmann M, Bechmann, Dimou L, Götz M. Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature Neuroscience 16:580-6 (2013) Cappello S, Böhringer CRJ, Bergami M, Conzelmann K-K, Ghanem A, Tomassy GS, Arlotta P, Mainardi M, Allegra M, Caleo M, van Hengel J, Brakebusch C, Götz M. A radial glia specific role of RhoA in double-cortex formation. Neuron 73:911-24 (2012) Beckervordersandforth R, Tripathi P, Ninkovic J, Bayam E, Lepier A, Stempfhuber B, Kirchhoff F, Hirrlinger J, Haslinger A, Chichung LD, Beckers J, Yoder B, Irmler M, Götz M. In vivo fate mapping and expression analysis reveals unique molecular hallmarks of prospectively isolated adult neural stem cells. Cell Stem Cell 7:744-58 (2010) Buffo A, Rite I, Tripathi P, Lepier A, Colak D, Horn A-P, Mori T, Götz M. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. PNAS 105:3581-86 (2008)

References

Worked examples

Example 1 — a first encounter with Magdalena Götz

Start with the simplest possible case. Write down what Magdalena Götz claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Magdalena Götz before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Magdalena Götz ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Magdalena Götz

In research: Magdalena Götz appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Magdalena Götz in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Magdalena Götz is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1962 births, Academic staff of LMU Munich, German women neuroscientists, so understanding it makes those chapters shorter.
In everyday life: Look for Magdalena Götz outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Magdalena Götz in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Magdalena Götz means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
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Frequently asked questions

What is Magdalena Götz in simple terms?

Magdalena Götz (born 17 January 1962) is a German neuroscientist. She is noted for her study of glial cells and holds a chair at LMU Munich's Department of Physiology.

Why does Magdalena Götz matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Magdalena Götz?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Magdalena Götz.