Malegapuru William Makgoba (born 1952 in Sekhukhune, South Africa) is a leading South African immunologist, physician, public health advocate, academic and former vice-chancellor of the University of KwaZulu-Natal. In 2013 he was recognised as "a pioneer in higher education transformation", by being awarded the Order of Mapungubwe in Silver.
Academic career Makgoba received an MBChB degree from the University of Natal Medical School in 1976 with merit in medicine. In 1979 he was named the first black Nuffield Dominion Fellow to the University of Oxford, where he completed his DPhil degree in human immunogenetics in 1983 under Professor Sir Andrew McMichael. The title of his thesis was "Studies on the polymorphism of HLA class II antigens". He went on to become the first senior registrar to fellow expatriate South African and President of Royal College of Physicians of London, Sir Raymond Hoffenberg, in 1983. He was Reader in Molecular Endocrinology at the Royal Postgraduate Medical School London (1990–94) He was the first black South African to be selected to the prestigious National Institute of Health's Fogarty Visiting Programme in the late 1980s. Makgoba was appointed the first black deputy vice-chancellor at the University of the Witwatersrand in 1995. Makgoba left Wits University to join the South African Medical Research Council. He was appointed the first black Chairperson of the MRC Board(1995-1998). He thereafter served as President of the South African Medical Research Council between 1999 and 2002 and was involved in developing South Africa's AIDS strategy and the SA AIDS Vaccine Initiative. Professor Makgoba joined the former University of Natal as its Vice-Chancellor in 2002, and oversaw its merger with the University of Durban-Westville into the University of KwaZulu-Natal. UKZN is one of the top five research-intensive universities in the country and ranked amongst the top 500 Universities in the World. During 2007–2008, the university raised 577 million South African rands (about 57 million Euros) in total research funding. Prof. Makgoba has been closely involved with the funding in 2011 of a new 4,000 square metre HIV and tuberculosis research Institute, KwaZulu-Natal Research Institute for TB and HIV (KRITH) at the university's medical school.
Achievements
Scientific contributions Working with Drs. Martin Sanders and Stephen Shaw and others at the National Cancer Institute, "were among the first to appreciate the importance of lymphocyte adhesion and these observations have helped shape the evolution of the field as follows:
appreciation of the importance of antigen-nonspecific adhesion to T cell antigen-specific recognition, demonstration that changes in adhesion molecule expression and function are cardinal features of naïve to memory cell differentiation and for co-discovering the first two heterophillic direct intercellular molecular adhesion pathways in biology ". He was instrumental in demonstrating the importance of adhesion molecules in T cell function through a series of what are now regarded as classic publications. Provided the first evidence that isoforms of the adhesion/ signaling molecule (ICAM-1) circulate in plasma and the circulating levels of isoform patterns might vary with inflammation and in different pathological states.
Fellowships and affiliations A former Deputy Vice-Chancellor at the University of Witwatersrand and ad hominem professor of molecular Immunology at the University of Witwatersrand's School of Pathology 1996–98, Professor Makgoba is
Fellow of the Royal College of Physicians of London 1990; Founding Member of the Academy of Science of South Africa; Foreign Associate member of the United States National Academy of Sciences' Institute of Medicine 2002; Fellow of the College of Physicians of South Africa ad eundem Fellow of Imperial College's Faculty of Medicine 2007 in recognition of contributions to "medical research, international public health and university administration". Professor Makgoba was appointed as member of the National Planning Commission of the Republic of South Africa Professor Makgoba was a member of National Working Group appointed by the late Educational Minister Kadar Asmal in year 2000, that recommended mergers and incorporations in the restructuring of Higher Education system in South Africa. In October 2011 he was elected as the new vice-president for Scientific Planning and Review of the prestigious Paris-based International Council for Science (ICSU). Chosen as chair of the Ministerial Oversight Committee on Transformation in SA Public Universities
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