Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the reversible chemical reaction:
The enzyme characterised from yeast combines guanosine diphosphate and mannose 1-phosphate to give guanosine diphosphate mannose, with pyrophosphate (PPi) as a byproduct.
Nomenclature This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. Common names in use include:
GDP mannose phosphorylase Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase GDP mannose phosphorylase GDP-mannose 1-phosphate guanylyltransferase Guanosine diphosphate-mannose 1-phosphate guanylyltransferase Guanosine diphosphomannose phosphorylase Mannose 1-phosphate guanylyltransferase GDP:D-mannose-1-phosphate guanylyltransferase
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