astronomy

Mario Rosemblatt

Mario Rosemblatt is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Mario Rosemblatt rather than just read about it. In short: Mario Rosemblatt is a Chilean immunologist. His research established that dendritic cells are responsible for imprinting the tissue-specific homing of T lymphocytes.

Key takeaways

Mario Rosemblatt belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Mario Rosemblatt to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Mario Rosemblatt from memory before moving on to harder problems.

Reference excerpt

Mario Rosemblatt is a Chilean immunologist. His research established that dendritic cells are responsible for imprinting the tissue-specific homing of T lymphocytes. He is currently Executive Director of Fundacion Ciencia para la Vida (FCV), a non profit institution that carries out scientific and technological research. He is Immunology Professor at the University of Chile and Universidad San Sebastián (2008), He received The Academic Excellence Award - Faculty of Sciences - University of Chle (2008) and the Basic Science Mentee/Mentor Award from The Transplantation Society, USA, among other Awards.

Biography Mario Rosemblatt earned his Ph.D. degree in immunology at Wayne State University. He has been Research Fellow in Medicine at Harvard University (1973) joining the group of Dr. Edgar Haber, Assistant Professor at Brown University (1976), Investigator at the Boston Biomedical Research Institute (1978) and the Association Against Cancer in France (1981). In 1983, he returned to Chile and joined the Faculty of Sciences at the University of Chile. He was Chairman of the Biology Department and Director of the team that established the degree in Biotechnology at the University of Chile, acting as the first Director of this program. In 1997 he joined the Fundación Ciencia para la Vida acting as its first Executive Director.

Research During his years at the Boston Biomedical Research Institute Dr. Rosemblatt was the first to publish a report on the use of monoclonal antibody technology to study muscle physiology. The main aspects of his research deals with studies related to the function of regulatory T cells. His team has demonstrated that although B cells and dendritic cells can generate regulatory T cells by themselves, a mixture of both antigen-presenting cells improves their capacity to efficiently generate regulatory T cells. He also has established that gut dendritic cells are responsible for the production of retinoic acid and therefore for the induction of a tolerogenic environment in the gut. As an immunologist he participated in the development of a salmon vaccine –presently in the market, licensed to Novartis- against the Pitsireckettsia salmonis a deadly pathogen that affects the salmon industry in Chile. Mario Rosemblatt is a member of the American Association of Immunologists, of the Transplantation Society, of the Chilean Society for Cell Biology and the Chilean Society of Immunology.

Publications

Selection of Papers Jørgensen TN, Alfaro J, Enriquez HL, Jiang C, Loo WM, Atencio S, Bupp MR, Mailloux CM, Metzger T, Flannery S, Rozzo SJ, Kotzin BL, Rosemblatt M., Bono MR, Erickson LD. Development of murine lupus involves the combined genetic contribution of the SLAM and FcgammaR intervals within the Nba2 autoimmune susceptibility locus. J Immunol. 15; 775-86, 2010 C. Moore, D. Sauma, P. Reyes, J. Morales, M. Rosemblatt, M.R. Bono and J.A. Fierro. Dendritic Cells and B Cells Cooperate in the Generation of CD4+CD25+Foxp3+ Allogeneic T Cells. Transplant. Proc. 42; 371-5, 2010 Elgueta R., Sepulveda F., E. Vilches F., Vargas L., Mora J.R., Bono M.R., Rosemblatt M. Imprinting of CCR9 on CD4 T cells requires IL-4 signalling on mesenteric lymph node dendritic cells. J. Immunol. 180; 6501-7, 2008 Gabrielle Faure-André, Pablo Vargas, Maria-Isabel Yuseff, Mélina Heuzé, Jheimmy Diaz, Danielle Lankar, Veronica Steri, Jeremy Manry, Stéphanie Hugues, Fulvia Vascotto, Jérôme Boulanger, Graça Raposo, Maria-Rosa Bono, Mario Rosemblatt, Matthieu Piel and Ana-Maria Lennon-Duménil. CD74, the MHC class II-associated Invariant Chain, regulates the motility and in vivo migration of dendritic cells. Science 322; 1705–1710, 2008 Bono MR, Elgueta R, Sauma D, Pino K, Osorio F, Michea, P, Fierro A, Rosemblatt M. The essential role of chemokines in the selective regulation of lymphocyte homing. Cytokine and Growth Factor Reviews. 18: (1-2): 33-43, 2007 Micah J. Benson, Karina Pino-Lagos, Mario Rosemblatt and Randolph J. Noelle. All-trans retinoic acid mediates enhanced Treg growth, differentiation and gut homing in the face of high levels of co-stimulation. J. Exp. Med. 204: 1765-74, 2007 M. Rosemblatt and M.R. Bono. “Functional consequences of immune cell adhesion to endothelial cells”. Current Pharmaceutical Design, 10: 109-120, 2004 J.R. Mora, M.R. Bono, N. Manjunath, W. Weninger, M. Rosemblatt, U.H. Von Andrian. "Peyer's patch dendritic cells provide tissue-specific instructions for effector T cell homing to the gut". Nature 424:88-93, 2003 L. I. Reyes, P. Escobar, M. R. Bono and M. Rosemblatt. “B lymphocyte adhesion to endothelial cells from human lymphoid tissue modulates tyrosine phosphorylation and endothelial cell activation”. J. Immunol. 169: 5881-5888, 2002 Ana-Maria Lennon-Duménil, Arnold H. Bakker, René Maehr, Herman S. Overkleeft, Mario Rosemblatt, Hidde L. Ploegh and Cécile Lagaudrière-Gesbert. "Analysis of protease in live antigen-presenting cells show regulation of the phagosomal proteolytic contents during dendritic cell activation ". J. Exp. Med. 169: 529-539, 2002 Rosemblatt M., Gaugler M.H., Leroy C., Coulombel L. Coexpression of two fibronectin receptors, VLA-4 and VLA-5 on immature erythroblastic precursor cells. J. Clinic. Invest. 87: 6, 1991. Rosemblatt M., Hidalgo C., Vergara C., Ikemoto N. Immunological and biochemical properties of transverse tubule membranes from rabbit skeletal muscle. J. Biol. Chem. 256: 8140, 1981 Rosemblatt M., Haber E. Isolation of a variable domain fragment from a homogeneous antibody heavy chain. Biochem. 17: 3877, 1978

… excerpt ends here. Continue reading the full article.

Illustrations

Worked examples

Example 1 — a first encounter with Mario Rosemblatt

Start with the simplest possible case. Write down what Mario Rosemblatt claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Mario Rosemblatt before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Mario Rosemblatt ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Mario Rosemblatt

In research: Mario Rosemblatt appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Mario Rosemblatt in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Mario Rosemblatt is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1941 births, Academic staff of the University of Chile, Chilean medical doctors, so understanding it makes those chapters shorter.
In everyday life: Look for Mario Rosemblatt outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Mario Rosemblatt in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Mario Rosemblatt means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Mario Rosemblatt out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Mario Rosemblatt in simple terms?

Mario Rosemblatt is a Chilean immunologist. His research established that dendritic cells are responsible for imprinting the tissue-specific homing of T lymphocytes.

Why does Mario Rosemblatt matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Mario Rosemblatt?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Mario Rosemblatt.