science

Meenhard Herlyn

Meenhard Herlyn is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Meenhard Herlyn rather than just read about it. In short: Meenhard Herlyn is an American researcher who works as director of the Wistar Institute Melanoma Research in Philadelphia. Herlyn obtained his D.V.M. degree from the University of Veterinary Medicine Hannover in 1970.

Key takeaways

Meenhard Herlyn belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Meenhard Herlyn to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Meenhard Herlyn from memory before moving on to harder problems.

Reference excerpt

Meenhard Herlyn is an American researcher who works as director of the Wistar Institute Melanoma Research in Philadelphia. Herlyn obtained his D.V.M. degree from the University of Veterinary Medicine Hannover in 1970. Following that, in 1976, he earned a D.Sc. in medical microbiology from LMU Munich. In 1976, he joined the Wistar Institute as an associate scientist, focusing on the emerging field of monoclonal antibodies—a groundbreaking technology that now underlies a significant portion of targeted therapeutics. Transitioning to the role of assistant professor in 1981, Herlyn established a renowned laboratory dedicated to studying melanoma biology, which remains highly regarded in the field to this day. His primary research focus is the underlying biology behind melanoma, the most aggressive form of skin cancer. Over the course of his career, he has been responsible for the use of three-dimensional artificial skin cultures to study tumor and normal cells, a clearer understanding of stem cells and how they relate to cancer, and signaling pathways related to cancer. The Wistar Melanoma (WM) cell lines that Herlyn has used and helped discover in his laboratory are responsible for a better understanding of the major steps of tumor progression in human cases of melanoma. In 2003, Herlyn helped launch the first International Melanoma Research Congress in Philadelphia, the first scientific meeting specifically aimed at melanoma scientists. This was done in collaboration with the Foundation for Melanoma Research. This collaboration was prompted with his first direct melanoma patient interaction after more than two decades of research on the disease. He also established the Society for Melanoma Research in 2004 and served as its president for three years. One of the more recent discoveries made by Herlyn's lab found that the diabetes drug phenformin could be used to treat certain slow-growing, drug-resistant tumor cells in melanoma. In December 2013, it was announced that Herlyn and his colleagues had received a five-year, $12.5 million program project grant (PO1) to continue research on melanoma from multiple angles. In May 2013, L'Oréal Paris announced that Herlyn would lead the Melanoma Research Alliance Team Science Award, which provides more than $750,000 over three years to research the prevention, treatment, and potential cures for melanoma. He is a member of the editorial board of the Cancer and Metastasis Reviews.

Select publications Balaburski, G.M., Leu, J.I., Beeharry, N., Hayik, S., Andrake, M.D., Zhang, G., Herlyn, M., Villanueva, J., Dunbrack, R.L., Yen, T., George, D.L., Murphy, M.E.: A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol. Cancer Res. 11:219-229, 2013. Krepler, C., Chunduru, S.K., Halloran, M.B., He, X., Xiao, M., Vultur, A., Villanueva, J., Mitsuuchi, Y., Neiman, E.M., Benetatos, C., Nathanson, K.L., Amaravadi, R.K., Pehamberger, H., McKinlay, M., and Herlyn, M.: The novel SMAC inhibitor birinapant exhibits potent activity against human melanoma cells. Clin. Cancer Res. 19: 1784-1794, 2013. Desai, B.M., Villanueva, J., Nguyen, T-T.K., Lioni, M., Xiao, M., Kong, J., Krepler, C., Vultur, A., Flaherty, K.T., Nathanson, K.L., Smalley, K.S.M., Herlyn, M.: The anti-melanoma activity of dinaciclib, a cyclin-dependent kinase inhibitor, is dependent on p53 signaling. PLoS One, 8(3):e59588 doi:10:1371/journal.pone.0059588, 2013. Vultur, A., Villanueva, J., Krepler, C., Rajan, G., Chen, Q., Li, L., Gimotty, P., Wilson, M., Hayden, J., Keeney, F., Nathanson, K.L., Herlyn, M. MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines. Oncogene April 29 [Epub ahead of print], 2013. Aird, K.M., Zhang, G., Li, H., Tu, Z., Bitler, B.G., Garipov, A., Wu, H., Wei, Z., Wagner, S.N., Herlyn, M., Zhang, R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 3:1-4, 2013.

References

External links Dr. Herlyn's lab page on The Wistar Institute's website

Illustrations

Worked examples

Example 1 — a first encounter with Meenhard Herlyn

Start with the simplest possible case. Write down what Meenhard Herlyn claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Meenhard Herlyn before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Meenhard Herlyn ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Meenhard Herlyn

In research: Meenhard Herlyn appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Meenhard Herlyn in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Meenhard Herlyn is common in secondary-school and first-year university syllabi. It links to neighbouring topics Cancer researchers, Living people, so understanding it makes those chapters shorter.
In everyday life: Look for Meenhard Herlyn outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Meenhard Herlyn” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Meenhard Herlyn in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Meenhard Herlyn means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Meenhard Herlyn out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Meenhard Herlyn in simple terms?

Why does Meenhard Herlyn matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Meenhard Herlyn?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Meenhard Herlyn.