astronomy

Meir Bialer

Meir Bialer is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Meir Bialer rather than just read about it. In short: Meir Bialer (Hebrew: מאיר ביאלר; born January 30, 1948) is an Israeli pharmacologist who is a David H. Eisenberg Emeritus (active) Professor of Pharmacy at the School of Pharmacy, Faculty of Medicine, of the Hebrew University of Jerusalem.

Key takeaways

Meir Bialer belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Meir Bialer to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Meir Bialer from memory before moving on to harder problems.

Reference excerpt

Meir Bialer (Hebrew: מאיר ביאלר; born January 30, 1948) is an Israeli pharmacologist who is a David H. Eisenberg Emeritus (active) Professor of Pharmacy at the School of Pharmacy, Faculty of Medicine, of the Hebrew University of Jerusalem.

Biography Bialer was born in Petach Tikva, Israel, to a Jewish family. He completed his service in the Israeli Army in 1971-73. He received his B.Sc. Pharm in Pharmacy in 1969, his M.Sc. in Medicinal Chemistry from The Hebrew University of Jerusalem in 1971, his MBA in 1976 and his PhD in Medicinal Chemistry from the same university in 1977, with a dissertation on "Antiviral Structure-Activity Relationship of Distamycin and its Derivatives." After post-doctoral studies at the University of Florida (1977–79) and University of Kentucky (1979–80), he became a Lecturer (1980–84) and then Senior Lecturer (1984–88) and then Associate Professor (1988–93) at the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. In 1993 he became a Full Professor at the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. Currently, he is serving as a David H. Eisenberg Emeritus (active) Professor at the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem. Bialer was president of the Israel League Against Epilepsy, a branch of the International League Against Epilepsy (ILAE), from 1996 to 2001, and as the chair of ILAE-Europe from 2009 to 2017. He also served as president of Israel Society of Clinical Pharmacy and Biopharmaceutics (ISCPB), a member of the European Society of Pharmaceutical Sciences (EUFEPS) (1991–2001).

Research work Bialer’s research interests include:

Pharmacokinetics of new antiepileptic drugs (AEDs) and pharmacokinetic-based design of new antiepileptics and CNS drugs. In this regard he has been utilizing structure pharmacokinetic pharmacodynamic relationship (SPPR) studies to design and develop new CNS drugs with better potency, lack of teratogenicity, and a wide safety margin; Pharmacokinetic analysis of new drugs, sustained release dosage forms, and novel drug delivery systems (DDS); Stereospecific pharmacokinetic and pharmacodynamic analysis of chiral drugs; Pharmacogenetics of CNS drugs; Pharmacoresistance to AEDs. In these areas, he has 264 peer-reviewed publications, and is an author of 16 book chapters. Since 1981 he has supervised 22 MSc students and 31 PhD students.

Awards A Fellow of the American Association of Pharmaceutical Sciences - AAPS (1992) Kaye Innovation Awards at The Hebrew University of Jerusalem (2000, 2006, and 2007) Ambassador for Epilepsy Award of The International League Against Epilepsy – ILLAE and The International Bureau for Epilepsy (IBE; 2001) European Epileptology Award (2022)

Personal life

Meir married Shoshana Novak in 1970. They have two children Michal Bialer-Mor Yosef and Oded Bialer, as well as five grandchildren: Adi, Omri and Roni Bialer and Adam and Eitan Mor Yosef.

Selected publications S. Eyal, B. Yagen, E. Sobol, Y. Altschuler, M. Shmuel and M. Bialer: The activity of antiepileptic drugs as histone deacetylase inhibitors. Epilepsia 45:737-744 (2004). M. Bialer, D.R. Doose, B. Murthy, C. Curtin, S-S Wang, R.E. Twyman and S. Schwabe: Pharmacokinetic interactions of topiramate. Clin. Pharmacokinet. 43:763-780 (2004). E. Perucca, J. French and M. Bialer. Developing novel antiepileptic drugs (AEDs): Challenges, incentives and recent advances. Lancet Neurol., 6:793-804 (2007). M. Bialer, S.J. Johannessen, H.J. Kupferberg, R.H. Levy, E. Perucca and T. Tomson: Progress report on new antiepileptic drugs: A summary of the Eight Eilat Conference (EILAT VIII). Epilepsy Res.73:1-52 (2007). M. Bialer. Generic products of antiepileptic drugs (AEDs): Is it an issue? Epilepsia, 48:1825-1832 (2007). M. Bialer, H. S. White. Key factors in the discovery and development of new antiepileptic drugs (AEDs). Nature Rev. Drug Discov. 9: 68-83 (2010). H. S. White, A. B. Alex, A. Pollock, N. Hen, T. Shekh-Ahmed, K. S. Wilcox, J. H. McDonough, J. P. Stables, D. Kaufmann, B. Yagen, B. Bialer. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia 53:134-146 (2012) M. Bialer. Chemical properties of antiepileptic drugs (AEDs). Adv. Drug Deliv. Rev. 64: 887-895 (2012). M. Bialer, P. Soares-da-Silva. Pharmacokinetics and drug interactions of eslicarbazepine acetate. Epilepsia.53: 935-946 (2012). M. Bialer, E. Perucca. Does Cannabidiol Have Antiseizure Activity Independent of its Interactions with Clobazam? An Appraisal of the Evidence from Randomized Controlled Trials. Epilepsia, 61: 1082-1089 (2020) R. Odi, D. Bibi, T. Wager, M. Bialer. A Perspective into the physicochemical and biopharmaceutic properties of marketed antiepileptic drugs - from phenobarbital to cenobamate and beyond. Epilepsia, 61:1543-1552 (2020). R. Odi, V. Franco, E. Perucca, M. Bialer. A perspective on bioequivalence and switchability of generic AED products. Epilepsia 62: 285-302 (2021). R. Odi, R.W. Invernizzi, T. Gallily, E. Perucca, M. Bialer. Fenfluramine repurposing from weight loss to epilepsy; what we do and do not know. Pharmacol Ther.226, 107866 (2021). M. Bilaer, E. Perucca. Lorcaserin for Dravet Syndrome- A potential advance over fenfluramine? CNS Drugs, 21:115-122 (2022).

References

Illustrations

Worked examples

Example 1 — a first encounter with Meir Bialer

Start with the simplest possible case. Write down what Meir Bialer claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Meir Bialer before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Meir Bialer ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Meir Bialer

In research: Meir Bialer appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Meir Bialer in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Meir Bialer is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1948 births, Academic staff of the Hebrew University of Jerusalem, Hebrew University of Jerusalem alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Meir Bialer outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Meir Bialer in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Meir Bialer means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Meir Bialer out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Meir Bialer in simple terms?

Why does Meir Bialer matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Meir Bialer?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Meir Bialer.