science

Mescaline-FLY

Mescaline-FLY is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Mescaline-FLY rather than just read about it. In short: Mescaline-FLY, also known as flyscaline, M-FLY, or MeO-2C-2,6-IFLY, is a putatively non-hallucinogenic serotonin receptor modulator of the phenethylamine, scaline, and FLY families. It is the FLY (benzodifuran) analogue of the psychedelic drug mescaline.

Key takeaways

Mescaline-FLY belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Mescaline-FLY to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Mescaline-FLY from memory before moving on to harder problems.

Reference excerpt

Mescaline-FLY, also known as flyscaline, M-FLY, or MeO-2C-2,6-IFLY, is a putatively non-hallucinogenic serotonin receptor modulator of the phenethylamine, scaline, and FLY families. It is the FLY (benzodifuran) analogue of the psychedelic drug mescaline.

Use and effects Mescaline-FLY is not known to have been tested in humans, and hence it is unknown whether it produces psychedelic effects in humans. However, based on its lack of psychedelic-like effects in animals, it may not be expected to be hallucinogenic in humans.

Pharmacology

Pharmacodynamics Mescaline-FLY shows affinity for the serotonin 5-HT2 receptors. Its affinities (Ki) were 335 to 4,443 nM for the serotonin 5-HT2A receptor, 205 to 302 nM for the serotonin 5-HT2B receptor, and 61.5 to 654 nM for the serotonin 5-HT2C receptor. The affinity of mescaline-FLY for the serotonin 5-HT2A receptor was only slightly higher than that of mescaline, whereas it showed several-fold higher affinity for the serotonin 5-HT2C receptor and about 2-fold higher affinity for the serotonin 5-HT2B receptor compared to mescaline. In a subsequent study, at the serotonin 5-HT2A receptor, its affinity (K0.5) was 243 nM and its EC50Tooltip half-maximal effective concentration (EmaxTooltip maximal efficacy) was 3,470 nM (57%), relative to respective values for mescaline of 801 nM and 2,700 nM (88%). Hence, whereas mescaline is a full agonist of the serotonin 5-HT2A receptor, mescaline-FLY is a moderate-efficacy partial agonist of the receptor. The drug failed to substitute for LSD in rodent drug discrimination tests, producing a maximum substitution of 29% at a dose of 55.2 μmol/kg, whereas mescaline fully substituted for LSD with an ED50Tooltip median effective dose of 33.5 μmol/kg. The lack of substitution with mescaline-FLY is in notable contrast to findings with other FLY drugs, such as 2C-B-FLY, DOB-FLY, and Bromo-DragonFLY.

History Mescaline-FLY was first described in the scientific literature by the lab of David E. Nichols and colleagues by 1995.

Society and culture

Legal status

Canada Mescaline-FLY is not a controlled substance in Canada as of 2025.

United States Mescaline-FLY is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also Substituted methoxyphenethylamine FLY (psychedelics) Scaline Hemi-flyscaline (mescaline-hemiFLY) NBOMe-mescaline 2,6-Dimethylmescaline

References

External links Mescaline-FLY - Isomer Design

Illustrations

Worked examples

Example 1 — a first encounter with Mescaline-FLY

Start with the simplest possible case. Write down what Mescaline-FLY claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Mescaline-FLY before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Mescaline-FLY ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Mescaline-FLY

In research: Mescaline-FLY appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Mescaline-FLY in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Mescaline-FLY is common in secondary-school and first-year university syllabi. It links to neighbouring topics David E. Nichols, Dihydrofurans, Drugs not assigned an ATC code, so understanding it makes those chapters shorter.
In everyday life: Look for Mescaline-FLY outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Mescaline-FLY in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Mescaline-FLY means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Mescaline-FLY out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Mescaline-FLY in simple terms?

Why does Mescaline-FLY matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Mescaline-FLY?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Mescaline-FLY.