Mesembrenone is an alkaloid found in Sceletium tortuosum (Kanna) and minor constituent of Lampranthus aureus and Lampranthus spectabilis. It can be consumed orally, smoked, or snorted. It is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is, a serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).
See also Other alkaloids present in Kanna include:
Mesembrine Mesembranol Tortuosamine
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