Metal bis(trimethylsilyl)amides

Metal bis(trimethylsilyl)amides (often abbreviated as metal silylamides) are coordination complexes composed of a cationic metal M with anionic bis(trimethylsilyl)amide ligands (the −N(Si(CH3)3)2 monovalent anion, or −N(Si(CH3)3)2 monovalent group, and are part of a broader category of metal amides. Due to the bulky hydrocarbon backbone metal bis(trimethylsilyl)amide complexes have low lattice energies and are lipophilic. For this reason, they are soluble in a range of nonpolar organic solvents, in contrast to simple metal halides, which only dissolve in reactive solvents. These steric bulky complexes are molecular, consisting of mono-, di-, and tetramers. Having a built-in base, these compounds conveniently react with even weakly protic reagents. The class of ligands and pioneering studies on their coordination compounds were described by Bürger and Wannagat. The ligands are often denoted hmds (e.g. M(N(SiMe3)2)3 = M(hmds)3) in reference to the hexamethyldisilazane from which they are prepared.

General methods of preparation Apart from group 1 and 2 complexes, a general method for preparing metal bis(trimethylsilyl)amides entails reactions of anhydrous metal chloride with an alkali metal bis(trimethylsilyl)amides via a salt metathesis reaction:

MCln + n Na(hmds) → M(hmds)n + n NaCl Alkali metal chloride formed as a by-product typically precipitates as a solid, allowing for its removal by filtration. The remaining metal bis(trimethylsilyl)amide is then often purified by distillation or sublimation.

Group 1 complexes

Lithium, sodium, and potassium bis(trimethylsilyl)amides are commercially available. When free of solvent, the lithium and sodium complexes are trimeric, and the potassium complex is dimeric in solid state. The lithium reagent may be prepared from n-butyllithium and bis(trimethylsilyl)amine:

nBuLi + HN(SiMe3)2 → Li(hmds) + butane The direct reaction of these molten metals with bis(trimethylsilyl)amine at high temperature has also been described:

M + HN(SiMe3)2 → MN(SiMe3)2 + 1/2 H2 Alkali metal silylamides are soluble in a range of organic solvents, where they exist as aggregates, and are commonly used in organic chemistry as strong sterically hindered bases. They are also extensively used as precursors for the synthesis other bis(trimethylsilyl)amide complexes (see below).

Group 2 complexes The calcium and barium complexes may be prepared via the general method, by treating calcium iodide or barium chloride with potassium or sodium bis(trimethylsilyl)amide. However, this method can result in potassium contamination. An improved synthesis involving the reaction of benzylpotassium with calcium iodide, followed by reaction with bis(trimethylsilyl)amine results in potassium-free material:

2 BnK + CaI2 + THF → Bn2Ca(thf) + KI Bn2Ca(thf) + 2 HN(SiMe3)2 → Ca(hmds)2 + 2 C6H5CH3 + THF Magnesium silylamides can be prepared from dibutylmagnesium; which is commercially available as a mixture of n-Bu and s-Bu isomers. It deprotonates the free amine to yield the magnesium bis(trimethylsilyl)amide, itself commercially available.

Bu2Mg + 2 HN(SiMe3)2 → Mg(hmds)2 + 2 butane In contrast to group 1 metals, the amine N-H in bis(trimethylsilyl)amine is not acidic enough to react with the group 2 metals, however complexes may be prepared via a reaction of tin(II) bis(trimethylsilyl)amide with the appropriate metal:

M + 2 HN(SiMe3)2 ↛ M(hmds)2 + H2 (M = Mg, Ca, Sr, Ba) M + Sn(hmds)2 → M(hmds)2 + Sn Long reaction times are required for this synthesis and when performed in the presence of coordinating solvents, such as dimethoxyethane, adducts are formed. Hence non-coordinating solvents such as benzene or toluene must be used to obtain the free complexes.

p-Block complexes Tin(II) bis(trimethylsilyl)amide is prepared from anhydrous tin(II) chloride and is commercially available. It is used to prepare other metal bis(trimethylsilylamide)s via transmetallation. The group 13 and bismuth(III) bis(trimethylsilyl)amides are prepared in the same manner; the aluminium complex may also be prepared by treating strongly basic lithium aluminium hydride with the parent amine:

LiAlH4 + 4 HN(SiMe3)2 → Li(hmds) + Al(hmds)3 + 4 H2 An alternative synthesis of tetrasulfur tetranitride entails the use of a metal bis(trimethylsilyl)amide [(Me3Si)2N]2S as a precursor with pre-formed S–N bonds. [(Me3Si)2N]2S is prepared by the reaction of lithium bis(trimethylsilyl)amide and sulfur dichloride (SCl2).

2 [(CH3)3Si]2NLi + SCl2 → [((CH3)3Si)2N]2S + 2 LiCl The metal bis(trimethylsilyl)amide [((CH3)3Si)2N]2S reacts with the combination of SCl2 and sulfuryl chloride (SO2Cl2) to form S4N4, trimethylsilyl chloride, and sulfur dioxide:

2[((CH3)3Si)2N]2S + 2SCl2 + 2SO2Cl2 → S4N4 + 8 (CH3)3SiCl + 2SO2 Tetraselenium tetranitride, Se4N4, is a compound analogous to tetrasulfur tetranitride and can be synthesized by the reaction of selenium tetrachloride with [((CH3)3Si)2N]2Se. The latter compound is a metal bis(trimethylsilyl)amide and can be synthesized by the reaction of selenium tetrachloride (SeCl4), selenium monochloride (Se2Cl2) and lithium bis(trimethylsilyl)amide.

d-Block complexes

In line with the general method, bis(trimethylsilyl)amides of transition metals are prepared by a reaction between the metal halides (typically chlorides) and an alkali metal bis(trimethylsilyl)amide. There is some variation however, for instance the synthesis Ti{N(SiMe3)2}3 and V{N(SiMe3)2}3 are prepared using the soluble precursors TiCl3(NMe3)2 or VCl3(NMe3)2, respectively. The melting and boiling points of the complexes decrease across the series, with Group 12 metals being sufficiently volatile to allow purification by distillation. Iron complexes are notable for having been isolated in both the ferrous (II) and ferric (III) oxidation states. Fe[N(SiMe3)2]3 can be prepared by treating iron trichloride with lithium bis(trimethylsilyl)amide and is paramagnetic as the high spin iron(III) contains 5 unpaired electrons.

FeCl3 + 3LiN(SiMe3)2 → Fe[N(SiMe3)2]3 + 3LiCl Similarly, the two coordinate Fe[N(SiMe3)2]2 complex is prepared by treating iron dichloride with lithium bis(trimethylsilyl)amide:

FeCl2 + 2LiN(SiMe3)2 → Fe[N(SiMe3)2]2 + 2LiCl

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