science

Methoxamine

Methoxamine is a science topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Methoxamine rather than just read about it. In short: Methoxamine, sold under the brand names Vasoxine, Vasoxyl, and Vasylox among others, is a sympathomimetic medication used as an antihypotensive agent. It has mostly or entirely been discontinued.

Key takeaways

Methoxamine belongs to science; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Methoxamine to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Methoxamine from memory before moving on to harder problems.

Reference excerpt

Methoxamine, sold under the brand names Vasoxine, Vasoxyl, and Vasylox among others, is a sympathomimetic medication used as an antihypotensive agent. It has mostly or entirely been discontinued. The drug is an α1-adrenergic receptor agonist.

Medical uses The long duration of action of methoxamine has been said to have rendered it obsolete in modern clinical practice.

Pharmacology Methoxamine is an α1-adrenergic receptor agonist. It is described as a long-acting α1-adrenergic receptor agonist and this is contrasted with phenylephrine which is said to be short-acting. Phenylephrine is 5 to 10 times more potent than methoxamine and has a 3-fold higher maximal effect.

Chemistry Methoxamine, also known as 2,5-dimethoxy-β-hydroxy-α-methylphenethylamine or as 2,5-dimethoxy-β-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative.

Analogues Analogues of methoxamine include desglymidodrine (2,5-dimethoxy-β-hydroxyphenethylamine), dimetofrine (3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine), 2,5-dimethoxyamphetamine (2,5-DMA), butaxamine ((1S,2S)-2,5-dimethoxy-β-hydroxy-N-tert-butylamphetamine), methoxyphenamine (2-methoxy-N-methylamphetamine), and β-hydroxyamphetamine (e.g., phenylpropanolamine, norpseudoephedrine), among others.

History Methoxamine was synthesized by 1944. It was marketed in the United States by 1949.

Society and culture

Names Methoxamine is the generic name of the drug and its INNTooltip International Nonproprietary Name and BANTooltip British Approved Name, while méthoxamine is its DCFTooltip Dénomination Commune Française and methoxamina is its DCITTooltip Denominazione Comune Italiana. In the case of the hydrochloride salt, its generic name is methoxamine hydrochloride and this is its USANTooltip United States Adopted Name, BANMTooltip British Approved Name, and JANTooltip Japanese Accepted Name. A synonym of methoxamine is methoxamedrine. The drug has been sold under brand names including Idasal, Mexan, Pressomin, Vasosterol, Vasoxine, Vasoxyl, and Vasylox.

Availability Methoxamine has been marketed in Canada, the Czech Republic, Ireland, Japan, Spain, the United Kingdom, and the United States and was available in these countries in 2000. However, it was discontinued in Canada and the United Kingdom by 2004. It has also been discontinued in the United States. By 2016, methoxamine appeared to remain available only in Japan.

See also Substituted β-hydroxyamphetamine DOx § Related compounds

References

Illustrations

Worked examples

Example 1 — a first encounter with Methoxamine

Start with the simplest possible case. Write down what Methoxamine claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In science, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Methoxamine before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Methoxamine ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Methoxamine

In research: Methoxamine appears in science research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Methoxamine in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Methoxamine is common in secondary-school and first-year university syllabi. It links to neighbouring topics Alpha1-adrenergic agonists, Antihypotensive agents, Beta-Hydroxyamphetamines, so understanding it makes those chapters shorter.
In everyday life: Look for Methoxamine outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Methoxamine in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Methoxamine means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Methoxamine out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Methoxamine in simple terms?

Methoxamine, sold under the brand names Vasoxine, Vasoxyl, and Vasylox among others, is a sympathomimetic medication used as an antihypotensive agent. It has mostly or entirely been discontinued.

Why does Methoxamine matter?

Because it connects several science ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Methoxamine?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Methoxamine.