Methyl trichloroacetate is an organochlorine compound with the chemical formula CCl3COOCH3. It is a colorless liquid. It is the methyl ester of trichloroacetic acid.
Synthesis Methyl trichloroacetate can be synthesized by an esterification reaction between trichloroacetic acid and methanol in the presence of an acid as a catalyst (e.g. sulfuric acid).
CCl3COOH + CH3OH → CCl3COOCH3 + H2O
Uses Methyl trichloroacetate is primarily used in organic synthesis, especially as an intermediate in the production of various pharmaceuticals and agrochemicals.
Reactions Methyl trichloroacetate methylates carboxylic acids with the loss of chloroform and carbon dioxide. Direct fluorination of liquid methyl trichloroacetate produces fluoromethyl trichloroacetate CCl3COOCH2F and difluoromethyl trichloroacetate CCl3COOCHF2.
Hazards Methyl trichloroacetate possesses hazards typical of chlorinated organic compounds, including toxicity and environmental hazards. It can cause skin and respiratory irritation and serious eye irritation. It is toxic when inhaled.
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