This is a compilation of databases, web portals, and servers used for cataloging microRNAs and their targets. MicroRNAs (miRNAs) represent an important class of small non-coding RNAs (ncRNAs) that regulate gene expression by targeting and binding to messenger RNAs (mRNAs). The binding between each microRNA and the selected mRNA occurs within the RNA-induced silencing complex (miRISC) and leads to decreased protein expression through translational repression and/or mRNA degradation. Since target recognition occurs through base pairing, several prediction models have been developed which aim to predict potential mRNA targets based on sequence complementarity and other features
These resources must be distinguished from databases that collect observed experimental interactions. Moreover, experimental evidence can be deduced from high-throughput experiments, which collect vast amounts of data but tend to be more error-prone, and low-throughput experiments, in which a single mRNA target or a few targets are tested. Although considerable efforts have been made to standardize annotation vocabulary and RNA identifiers to support data integration and improve clarity for readers, significant discrepancies in annotation criteria still exist across databases, making it difficult for users to determine what constitutes a bona fide interactor . .
microRNA target gene databases
microRNA databases
References
Further reading Lee, RC; Ambros V (2001). "An extensive class of small RNAs in Caenorhabditis elegans". Science. 294 (5543): 862–864. Bibcode:2001Sci...294..862L. doi:10.1126/science.1065329. PMID 11679672. S2CID 33480585. Ambros, V (2001). "microRNAs: tiny regulators with great potential". Cell. 107 (7): 823–826. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
External links starBase database StarScan tool Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks miRBase database deepBase database TargetScan picTar miRecords database TarBase database Target ID Library miRTarBase database Archived 2011-03-24 at the Wayback Machine MBSTAR tool