The microcirculation is the circulation of the blood in the smallest blood vessels, the microvessels of the microvasculature present within organ tissues. The microvessels include terminal arterioles, metarterioles, capillaries, and venules. Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins. In addition to these blood vessels, the microcirculation also includes lymphatic capillaries and collecting ducts. The main functions of the microcirculation are the delivery of oxygen and nutrients and the removal of carbon dioxide (CO2). It also serves to regulate blood flow and tissue perfusion, thereby affecting blood pressure and responses to inflammation which can include edema (swelling). Most vessels of the microcirculation are lined by flattened cells of the endothelium and many of them are surrounded by contractile cells called pericytes. The endothelium provides a smooth surface for the flow of blood and regulates the movement of water and dissolved materials in the interstitial plasma between the blood and the tissues. The vascular endothelium also plays an important regulatory role in microcirculatory function. Endothelial cells respond to biochemical and mechanical stimuli and regulate vascular tone through the release of vasoactive mediators such as nitric oxide, prostacyclin, and endothelin. The microcirculation contrasts with macrocirculation, which is the circulation of blood to and from the organs.
Structure
Microvessels
The vessels on the arterial side of the microcirculation are called the arterioles, which are well innervated, are surrounded by smooth muscle cells, and are 10-50 μm in diameter. Arterioles carry the blood to the capillaries, which are not innervated, have no smooth muscle, and are about 5–8 μm in diameter. Blood flows out of the capillaries into the venules, which have little smooth muscle and are 10–200 μm. The blood flows from the venules into the veins. Metarterioles connect arterioles and capillaries. A tributary to the venules is known as a thoroughfare channel. The microcirculation has three major components: pre-capillary, capillary, and post-capillary. In the pre-capillary sector, arterioles, and precapillary sphincters participate. Their function is to regulate blood flow before it enters the capillaries and venules by the contraction and relaxation of the smooth muscle found on their walls. The second sector is the capillary sector, which is represented by the capillaries, where substance and gas exchange between blood and interstitial fluid takes place. Finally, the post-capillary sector is represented by the post-capillary venules, which are formed by a layer of endothelial cells that allow free movement of some substances.
Microanatomy Most vessels of the microcirculation are lined by flattened cells of the endothelium and many of them are surrounded by contractile cells called pericytes. The endothelium provides a smooth surface for the flow of blood and regulates the movement of water and dissolved materials in the interstitial plasma between the blood and the tissues. The endothelium also produces molecules that discourage the blood from clotting unless there is a leak. Pericyte cells can contract and decrease the size of the arterioles and thereby regulate blood flow and blood pressure.
Function In addition to these blood vessels, the microcirculation also includes lymphatic capillaries and collecting ducts. The main functions of the microcirculation are the delivery of oxygen and nutrients and the removal of carbon dioxide (CO2). It also serves to regulate blood flow and tissue perfusion thereby affecting blood pressure and responses to inflammation which can include edema (swelling).
Regulation The regulation of tissue perfusion occurs in microcirculation. There, arterioles control the flow of blood to the capillaries. Arterioles contract and relax, varying their diameter and vascular tone, as the vascular smooth muscle responds to diverse stimuli. Distension of the vessels due to increased blood pressure is a fundamental stimulus for muscle contraction in arteriolar walls. As a consequence, microcirculation blood flow remains constant despite changes in systemic blood pressure. This mechanism is present in all tissues and organs of the human body. In addition, the nervous system participates in the regulation of microcirculation. The sympathetic nervous system activates the smaller arterioles, including terminals. Noradrenaline and adrenaline have effects on alpha and beta adrenergic receptors. Other hormones (catecholamine, renin-angiotensin, vasopressin, and atrial natriuretic peptide) circulate in the bloodstream and can have an effect on the microcirculation causing vasodilation or vasoconstriction. Many hormones and neuropeptides are released together with classical neurotransmitters. Arterioles respond to metabolic stimuli that are generated in the tissues. When tissue metabolism increases, catabolic products accumulate leading to vasodilation. The endothelium begins to control muscle tone and arteriolar blood flow tissue. Endothelial function in the circulation includes the activation and inactivation of circulating hormones and other plasma constituents. There are also synthesis and secretion of vasodilator and vasoconstrictor substances for modifying the width as necessary. Variations in the flow of blood that circulates by arterioles are capable of responses in endothelium. In addition to biochemical signals, mechanical forces generated by blood flow influence endothelial function. These forces, known as shear stress, are sensed by endothelial cells and converted into biochemical signals in a process known as mechanotransduction. Shear stress plays an important role in the regulation of nitric oxide production and microvascular perfusion.
Microvascular dysfunction Microvascular dysfunction refers to structural or functional abnormalities of the microcirculation that impair tissue perfusion. It may result from endothelial dysfunction, altered vascular tone, or structural changes in the microvascular network. Microvascular dysfunction has been associated with several diseases including diabetes mellitus, sepsis, cardiovascular disease and chronic inflammatory disorders.
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