biology

Mir-124 microRNA precursor family

Mir-124 microRNA precursor family is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Mir-124 microRNA precursor family rather than just read about it. In short: The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373), nematode worms (MI0000302), mouse (MI0000150) and human (MI0000443). The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3′ arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells.

Key takeaways

Mir-124 microRNA precursor family belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Mir-124 microRNA precursor family to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Mir-124 microRNA precursor family from memory before moving on to harder problems.

Reference excerpt

The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373), nematode worms (MI0000302), mouse (MI0000150) and human (MI0000443). The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3′ arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation. However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.

Targets of miR-124 Visvanathan et al. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1). Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells. Arrant et al. wrote that miR-124 changes glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia.

Clinical medicine Presence of the G allele, compared to the C allele, in SNP rs531564 in pri-miR-124-1, measured by PCR-RFLP in leukocyte DNA, is linked to a reduced risk of gastric cancer (e.g. GG v CC OR 0.34 95% CI 0.19-0.59, p<0.001).

References

External links

Page for miR-124 microRNA precursor family at Rfam miRBase family for miR-124

Illustrations

Worked examples

Example 1 — a first encounter with Mir-124 microRNA precursor family

Start with the simplest possible case. Write down what Mir-124 microRNA precursor family claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Mir-124 microRNA precursor family before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Mir-124 microRNA precursor family ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Mir-124 microRNA precursor family

In research: Mir-124 microRNA precursor family appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Mir-124 microRNA precursor family in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Mir-124 microRNA precursor family is common in secondary-school and first-year university syllabi. It links to neighbouring topics MicroRNA, MicroRNA precursor families, Molecular and cellular biology stubs, so understanding it makes those chapters shorter.
In everyday life: Look for Mir-124 microRNA precursor family outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Mir-124 microRNA precursor family in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Mir-124 microRNA precursor family means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Mir-124 microRNA precursor family out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Mir-124 microRNA precursor family in simple terms?

Why does Mir-124 microRNA precursor family matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Mir-124 microRNA precursor family?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Mir-124 microRNA precursor family.