In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Expression in cancers Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer. Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change. This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states. miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.
See also MicroRNA
References
Further reading Wang, W.; Zhao, L. -J.; Tan, Y. -X.; Ren, H.; Qi, Z. -T. (2012). "MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma". Carcinogenesis. 33 (5): 1113–1120. doi:10.1093/carcin/bgs113. PMC 3334515. PMID 22362728.
External links
Page for mir-592 microRNA precursor family at Rfam