In molecular biology mir-601 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Molecular pathway regulation miR-601 has been found to affect a number of different cell signalling pathways, more specifically bringing about downregulation of Fas-induced apoptosis and NF-kappa B signalling. There is additionally upregulation of the actin cytoskeleton and increased negative regulation of translational initiation by miR-601. The importance of NF-kappa B in tumour cell proliferation and enhanced survival means that miR-601 mimics may hold a lot of promise for prevention or treatment of carcinogenesis. miR-602 has further been linked to the development and progression of gastric cancer, with levels significantly upregulated compared with normal gastric tissue.
See also MicroRNA
References
External links
Page for mir-601 microRNA precursor family at Rfam