In molecular biology mir-885 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-885-5p in neuroblastoma The miR-885-5p form of this microRNA acts as a tumour suppressor in neuroblastoma, through interference with cell cycle progression and cell survival. It is found at 3p25.3, a chromosome region frequently deleted in primary neuroblastoma, and expression results in p53 protein accumulation and pathway activation. Altered expression of multiple genes is observed with miR-885-5p, including the CDK2 and MCM5 genes encoding cyclin-dependent kinase 2 and mini-chromosome maintenance protein MCM5, and also with several p53 target genes.
Biological Implication
Clinical Biomarker Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions. similarly, miR-885-5p found as a potential marker for liver disease condition. It is significantly elevated in the patients sera with liver pathologies, and researcher suggested that serum miRNAs could serve as novel complementary biomarkers for the detection and assessment of liver pathologies. These unique miRNAs may be clinically applicable to predict prognosis and distant metastasis in colorectal cancer (CRC). The direct comparison of expression patterns of metastasis-specific microRNAs (miRNAs) in primary CRCs (pCRCs) and matched liver metastases (LMs) provides a feasibility of their clinical application as metastasis-specific biomarkers. In a clinical study it has been found that miR-885-5p is increased in plasma from pre-eclampsia compared with healthy pregnant women, and it is released into circulation mainly inside exosomes.
Cancer In search of an effective therapeutic strategy for improving colon cancer treatment, a novel role of miR-885-3p has been observed in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor, and provide new evidence that targeting miRNAs might be an effective therapeutic strategy.
See also MicroRNA
References
Further reading Huang, Y.; Chuang, A. Y.; Ratovitski, E. (2011). "Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure". Cell Cycle. 10 (22): 3938–3947. doi:10.4161/cc.10.22.18107. PMC 3266119. PMID 22071691. Yan, W.; Zhang, W.; Sun, L.; Liu, Y.; You, G.; Wang, Y.; Kang, C.; You, Y.; Jiang, T. (2011). "Identification of MMP-9 specific microRNA expression profile as potential targets of anti-invasion therapy in glioblastoma multiforme". Brain Research. 1411: 108–115. doi:10.1016/j.brainres.2011.07.002. PMID 21831363. S2CID 206327968. Tömböl, Z. F.; Eder, K.; Kovács, A.; Szabó, P. M.; Kulka, J.; Likó, I. N.; Zalatnai, A.; Rácz, G.; Tóth, M. S.; Patócs, A.; Falus, A. S.; Rácz, K. R.; Igaz, P. (2010). "MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas". Modern Pathology. 23 (12): 1583–1595. doi:10.1038/modpathol.2010.164. PMID 20818339. Gui, J.; Tian, Y.; Wen, X.; Zhang, W.; Zhang, P.; Gao, J.; Run, W.; Tian, L.; Jia, X.; Gao, Y. (2011). "Serum microRNA characterization identifiesmiR-885-5pas a potential marker for detecting liver pathologies". Clinical Science. 120 (5): 183–193. doi:10.1042/CS20100297. PMC 2990200. PMID 20815808. Guled, M.; Lahti, L.; Lindholm, P. M.; Salmenkivi, K.; Bagwan, I.; Nicholson, A. G.; Knuutila, S. (2009). "CDKN2A,NF2, andJUNare dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis". Genes, Chromosomes and Cancer. 48 (7): 615–623. doi:10.1002/gcc.20669. PMID 19396864. S2CID 22482567.
External links
Page for mir-885 microRNA precursor family at Rfam