biology

Mirit I. Aladjem

Mirit I. Aladjem is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Mirit I. Aladjem rather than just read about it. In short: Mirit I. Aladjem (Hebrew: מירית אלעדגם) is an Israeli-American biologist researching cellular signaling pathways that regulate DNA synthesis.

Key takeaways

Mirit I. Aladjem belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Mirit I. Aladjem to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Mirit I. Aladjem from memory before moving on to harder problems.

Reference excerpt

Mirit I. Aladjem (Hebrew: מירית אלעדגם) is an Israeli-American biologist researching cellular signaling pathways that regulate DNA synthesis. She is a senior investigator in the National Cancer Institute's developmental therapeutics branch and head of the DNA replication group.

Education Aladjem completed a Ph.D. at Tel Aviv University. She was a research associate at the Weizmann Institute of Science and then a postdoctoral fellow and a Leukemia Society Special Fellow at the Salk Institute for Biological Studies.

Career and research

Aladjem joined the National Cancer Institute's Laboratory of Molecular Pharmacology/Developmental Therapeutics Branch in October 1999 and was appointed a senior investigator in 2007. Aladjem's studies focus on cellular signaling pathways that modulate chromatin to regulate chromosome duplication and cell cycle progression. Aladjem’s team was the first to map replication origins on a whole genome scale, demonstrating a strong association between replication, histone modifications and chromatin packaging. Her current studies identified proteins that dictate whether particular chromatin regions would replicate during normal growth and after exposure to anti-cancer therapy.

Notable publications Novère, Nicolas Le; Hucka, Michael; Mi, Huaiyu; Moodie, Stuart; Schreiber, Falk; Sorokin, Anatoly; Demir, Emek; Wegner, Katja; Aladjem, Mirit I; Wimalaratne, Sarala M; Bergman, Frank T; Gauges, Ralph; Ghazal, Peter; Kawaji, Hideya; Li, Lu; Matsuoka, Yukiko; Villéger, Alice; Boyd, Sarah E; Calzone, Laurence; Courtot, Melanie; Dogrusoz, Ugur; Freeman, Tom C; Funahashi, Akira; Ghosh, Samik; Jouraku, Akiya; Kim, Sohyoung; Kolpakov, Fedor; Luna, Augustin; Sahle, Sven; Schmidt, Esther; Watterson, Steven; Wu, Guanming; Goryanin, Igor; Kell, Douglas B; Sander, Chris; Sauro, Herbert; Snoep, Jacky L; Kohn, Kurt; Kitano, Hiroaki (2009). "The Systems Biology Graphical Notation". Nature Biotechnology. 27 (8). Nature Portfolio: 735–741. doi:10.1038/nbt.1558. ISSN 1087-0156. PMID 19668183. S2CID 11156729.

References

External links Mirit I. Aladjem publications indexed by Google Scholar Mirit I. Aladjem's publications indexed by the Scopus bibliographic database. (subscription required) LinkedIn

Illustrations

Worked examples

Example 1 — a first encounter with Mirit I. Aladjem

Start with the simplest possible case. Write down what Mirit I. Aladjem claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Mirit I. Aladjem before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Mirit I. Aladjem ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Mirit I. Aladjem

In research: Mirit I. Aladjem appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Mirit I. Aladjem in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Mirit I. Aladjem is common in secondary-school and first-year university syllabi. It links to neighbouring topics 21st-century American biologists, 21st-century American women civil servants, 21st-century American women scientists, so understanding it makes those chapters shorter.
In everyday life: Look for Mirit I. Aladjem outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Mirit I. Aladjem in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Mirit I. Aladjem means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Mirit I. Aladjem out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Mirit I. Aladjem in simple terms?

Mirit I. Aladjem (Hebrew: מירית אלעדגם) is an Israeli-American biologist researching cellular signaling pathways that regulate DNA synthesis.

Why does Mirit I. Aladjem matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Mirit I. Aladjem?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Mirit I. Aladjem.