biology

Mostafa Ronaghi

Mostafa Ronaghi is a biology topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Mostafa Ronaghi rather than just read about it. In short: Mostafa Ronaghi (Persian: مصطفی رونقی; born 1968) is an Iranian molecular biologist, specializing in DNA sequencing methodology. As of 2008, he was the Chief Technology Officer and Senior Vice President at Illumina.

Key takeaways

Mostafa Ronaghi belongs to biology; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Mostafa Ronaghi to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Mostafa Ronaghi from memory before moving on to harder problems.

Reference excerpt

Mostafa Ronaghi (Persian: مصطفی رونقی; born 1968) is an Iranian molecular biologist, specializing in DNA sequencing methodology. As of 2008, he was the Chief Technology Officer and Senior Vice President at Illumina.

Early life and education

Mostafa Ronaghi was born in 1968. He earned his Ph.D. from the Royal Institute of Technology in Sweden in 1998.

Career

Ronaghi was a principal investigator and Senior Research Associate at the Stanford Genome Technology Center at Stanford University, prior to working at Illumina), where he focused on developing analytical techniques for molecular diagnostics. He is principal investigator for several grants including grants from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health for the development of array-based pyrosequencing. In 1998, Ronaghi, Pål Nyren, and Mathias Uhlen described a solution-based variant of the pyrosequencing technology, and co-founded Pyrosequencing AB (renamed to Biotage in 2003). He co-invented molecular inversion probe assays, and co-founded ParAllele BioScience to develop this multiplexed technology for genetic testing. ParAllele was acquired by Affymetrix in May 2005. In 2005, Ronaghi co-founded NextBio, a search engine for life science data. As of 2008, he was serving as the Chief Technology Officer and Senior Vice President at Illumina. NextBio was acquired by Illumina in 2013. He also serves on the board of directors of IntegenX and Aurora Biofuels. In 2008, Ronaghi and Helmy Eltoukhy co-founded Avantome, a DNA sequencing company that was acquired by Illumina in July 2008.

Publications Among his peer-reviewed journal articles are the publications describing pyrosequencing and molecular inversion probe assays, and other techniques:

Absalan, F; Ronaghi, M (2007). "Molecular Inversion Probe Assay". Comparative Genomics. Methods in Molecular Biology. Vol. 396. pp. 315–30. doi:10.1007/978-1-59745-515-2_20. ISBN 978-1-934115-37-4. PMID 18025701. Hardenbol, P; Banér, J; Jain, M; Nilsson, M; Namsaraev, EA; Karlin-Neumann, GA; Fakhrai-Rad, H; Ronaghi, M; Willis, TD; Landegren, U; Davis, RW (Jun 2003). "Multiplexed genotyping with sequence-tagged molecular inversion probes". Nature Biotechnology. 21 (6): 673–8. doi:10.1038/nbt821. PMID 12730666. S2CID 17619191. Talasaz, AH; Nemat-Gorgani, M; Liu, Y; et al. (Oct 2006). "Prediction of protein orientation upon immobilization on biological and nonbiological surfaces". Proceedings of the National Academy of Sciences. 103 (40): 14773–8. Bibcode:2006PNAS..10314773T. doi:10.1073/pnas.0605841103. PMC 1576295. PMID 17001006. Ronaghi, M (Jan 2001). "Pyrosequencing sheds light on DNA sequencing". Genome Research. 11 (1): 3–11. doi:10.1101/gr.11.1.3. PMID 11156611. Ronaghi, M; Uhlén, M; Nyrén, P (Jul 1998). "A sequencing method based on real-time pyrophosphate". Science. 281 (5375): 363–365. doi:10.1126/science.281.5375.363. PMID 9705713. S2CID 26331871. Ronaghi, M; Karamohamed, S; Pettersson, B; Uhlén, M; Nyrén, P (Nov 1996). "Real-time DNA sequencing using detection of pyrophosphate release". Analytical Biochemistry. 242 (1): 84–9. doi:10.1006/abio.1996.0432. PMID 8923969. He also holds about 20 patents.

References

[Pyrosequencing Array for DNA Sequencing]

External links Stanford Genome Technology Center NextBio IntegenX, Inc. Aurora Biofuels

Illustrations

Worked examples

Example 1 — a first encounter with Mostafa Ronaghi

Start with the simplest possible case. Write down what Mostafa Ronaghi claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In biology, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Mostafa Ronaghi before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Mostafa Ronaghi ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Mostafa Ronaghi

In research: Mostafa Ronaghi appears in biology research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Mostafa Ronaghi in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Mostafa Ronaghi is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1968 births, American people of Iranian descent, Iranian biologists, so understanding it makes those chapters shorter.
In everyday life: Look for Mostafa Ronaghi outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Mostafa Ronaghi in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Mostafa Ronaghi means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Mostafa Ronaghi out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Mostafa Ronaghi in simple terms?

Why does Mostafa Ronaghi matter?

Because it connects several biology ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Mostafa Ronaghi?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Mostafa Ronaghi.