Mugineic acid is the organic compound consisting of a azetidine group and three carboxylates. A colorless solid, it is a siderophore. More specifically, it is a phytosiderophore, i.e. a plant-produced siderophore. It functions as an iron accumulating agent for barley and other plants. Related phytosiderophores include nicotianamine and avenic acid.
It is biosynthesized from S-methylmethionine. The compound binds metal ions as a hexadentate ligand.
Biosynthesis Mugineic acid is a derivative of the nicotianamine, a metal-chelating molecule ubiquitous in higher plants that is produced from three molecules of S-adenosyl methionine by the enzyme nicotianamine synthase. The immediate precursor is 2'-deoxymugineic acid which is produced from nicotianamine by two reactions, catalysed by nicotianamine aminotransferase and 3''-deamino-3''-oxonicotianamine reductase.
This is followed by insertion of another hydroxyl group, catalysed by the alpha-ketoglutarate-dependent hydroxylase, 2'-deoxymugineic-acid 2'-dioxygenase:
Mugineic acid is also used as a precursor for the synthesis of other phytosiderophores which play a key role in iron uptake from the soil in graminaceous plants.
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![Mugineic acid: Structure of Co(III) complex of tetra-deprotonated mugineic acid (as sodium salt, not shown).[2][3]](https://upload.wikimedia.org/wikipedia/commons/thumb/6/68/BAVJOX11.png/500px-BAVJOX11.png?utm_source=en.wikipedia.org&utm_campaign=parser&utm_content=thumbnail)

