In enzymology, a myristoyl-CoA 11-(E) desaturase (EC 1.14.99.31) is an enzyme that catalyzes the chemical reaction
myristoyl-CoA + NAD(P)H + H+ + O2 ⇌ {\displaystyle \rightleftharpoons } (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O The 5 substrates of this enzyme are myristoyl-CoA, NADH, NADPH, H+, and O2, whereas its 4 products are (E)-11-tetradecenoyl-CoA, NAD+, NADP+, and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O miscellaneous. The systematic name of this enzyme class is n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating].
References
Navaro I, Font I, Fabrias G, Camps F (1997). "Stereospecificity of the (E)- and (Z)-11 myristoyl desaturases in the biosynthesis of Spodoptera littoralis sex pheromone". J. Am. Chem. Soc. 119 (46): 11335–11336. Bibcode:1997JAChS.11911335N. doi:10.1021/ja972577v.
