N-Ethyl-2C-B, also known as 2C-B-E, is a psychedelic drug of the phenethylamine and 2C families related to 2C-B. It is the N-ethyl derivative of 2C-B. The drug shows affinity for the serotonin 5-HT2A and 5-HT2C receptors (Ki = 40–330 nM and 1,930 nM, respectively). Its affinities for these receptors were 10–40-fold and 54-fold lower than those of 2C-B, respectively. N-Ethyl-2C-B has been reported to be a potent full agonist of the serotonin 5-HT2A receptor, with an EC50Tooltip half-maximal effective concentration of 3.39 nM and an EmaxTooltip maximal efficacy of 106% It was 8-fold more potent as a serotonin 5-HT2A receptor agonist in vitro than LSD in the same study. The chemical synthesis of N-ethyl-2C-B has been described. Analogues of N-ethyl-2C-B include 2C-B, N-methyl-2C-B, N-methyl-2C-I, N-methyl-DOB, N-benzyl-2C-B, and 25B-NBOMe, among others. N-Ethyl-2C-B was first described in the scientific literature by Richard Glennon and colleagues by 1994. It was encountered as a novel designer drug in Finland in 2007. The drug is a controlled substance in Finland. In addition, it is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 2C (psychedelics) βk-2C-B
References
External links N-Ethyl-2C-B - Isomer Design Anyone have experience with N-ethyl-2C-B AKA 2C-B-E? - r/researchchemicals - Reddit



