In enzymology, a NADPH peroxidase (EC 1.11.1.2) is an enzyme that catalyzes the chemical reaction
NADPH + H+ + H2O2 ⇌ {\displaystyle \rightleftharpoons } NADP+ + 2 H2O The 3 substrates of this enzyme are NADPH, H+, and H2O2, whereas its two products are NADP+ and H2O. This enzyme belongs to the family of oxidoreductases, specifically those acting on a peroxide as acceptor (peroxidases). The systematic name of this enzyme class is NADPH:hydrogen-peroxide oxidoreductase. Other names in common use include TPNH peroxidase, NADP peroxidase, nicotinamide adenine dinucleotide phosphate peroxidase, TPN peroxidase, triphosphopyridine nucleotide peroxidase, and NADPH2 peroxidase.
References
Conn EE, Kraemer LM, Liu PN, Vennesland B (1952). "The aerobic oxidation of reduced triphosphopyridine nucleotide by a wheat germ enzyme system". J. Biol. Chem. 194 (1): 143–51. doi:10.1016/S0021-9258(18)55863-4. PMID 14927602.
