chemistry

NBOMe-escaline

NBOMe-escaline is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand NBOMe-escaline rather than just read about it. In short: NBOMe-escaline, also known as escaline-NBOMe or as N-(2-methoxybenzyl)-4-ethoxy-3,5-dimethoxyphenethylamine, is a serotonin receptor agonist and putative psychedelic drug of the phenethylamine, scaline, and N-benzylphenethylamine (NBOMe) families. It is the N-(2-methoxybenzyl) derivative of escaline.

Key takeaways

NBOMe-escaline belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect NBOMe-escaline to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of NBOMe-escaline from memory before moving on to harder problems.

Reference excerpt

NBOMe-escaline, also known as escaline-NBOMe or as N-(2-methoxybenzyl)-4-ethoxy-3,5-dimethoxyphenethylamine, is a serotonin receptor agonist and putative psychedelic drug of the phenethylamine, scaline, and N-benzylphenethylamine (NBOMe) families. It is the N-(2-methoxybenzyl) derivative of escaline. The drug acts as a potent serotonin 5-HT2A receptor partial agonist, with an affinity (A2) of 0.537 nM, an activational potency (KP) of 7.08 nM, and an intrinsic activity (EmaxTooltip maximal efficacy) of 48%. As a serotonin 5-HT2A receptor agonist in vitro, it was 7-fold more potent than NBOMe-mescaline, 50-fold more potent than escaline, and 476-fold more potent than mescaline. NBOMe-escaline was first described in the scientific literature by Heinz Pertz and colleagues by 1999. Along with NBOMe-mescaline, it was one of the first psychedelic N-benzylphenethylamines to be discovered, slightly preceding the publication of 25-NB drugs like 25I-NBOMe by the same group of researchers. NBOMe-escaline is not a controlled substance in Canada as of 2025.

See also Scaline N-Benzylphenethylamine NBOMe-mescaline

References

External links NBOMe-escaline - Isomer Design

Illustrations

Worked examples

Example 1 — a first encounter with NBOMe-escaline

Start with the simplest possible case. Write down what NBOMe-escaline claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to NBOMe-escaline before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about NBOMe-escaline ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of NBOMe-escaline

In research: NBOMe-escaline appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses NBOMe-escaline in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: NBOMe-escaline is common in secondary-school and first-year university syllabi. It links to neighbouring topics 5-HT2A agonists, Drugs not assigned an ATC code, Ethoxy compounds, so understanding it makes those chapters shorter.
In everyday life: Look for NBOMe-escaline outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study NBOMe-escaline in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what NBOMe-escaline means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain NBOMe-escaline out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is NBOMe-escaline in simple terms?

Why does NBOMe-escaline matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study NBOMe-escaline?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on NBOMe-escaline.