NP3-146 (NLRP3-IN-5) is an experimental drug which acts as an inhibitor of the NLRP3 inflammasome. It inhibits the release of interleukin-1β and interleukin-18 which is usually triggered by inflammatory stimuli, and so terminates the resulting signalling cascade. It is used for research into various conditions in which chronic inflammation plays a role.
See also Bay 11-7082 YQ128
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