chemistry

Nagasuma Chandra

Nagasuma Chandra is a chemistry topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nagasuma Chandra rather than just read about it. In short: Nagasuma Chandra is an Indian structural biologist, biochemist and a professor at the department of biochemistry of the Indian Institute of Science. She is known for her studies on Mycobacterium tuberculosis.

Key takeaways

Nagasuma Chandra belongs to chemistry; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Nagasuma Chandra to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Nagasuma Chandra from memory before moving on to harder problems.

Reference excerpt

Nagasuma Chandra is an Indian structural biologist, biochemist and a professor at the department of biochemistry of the Indian Institute of Science. She is known for her studies on Mycobacterium tuberculosis. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences in 2008.

Biography

Nagasuma Chandra, born in the south Indian state of Karnataka, completed her undergraduate (BPharm) and post-graduate (MPharm) studies at the Bangalore University and moved to the UK from where she secured a PhD from the University of Bristol in 1992. She did her post-doctoral work at the Molecular Biophysics Unit (MBU) of the Indian Institute of Sciences (IISc) from 1992 to 1997 and joined IISc as a research scientist the same year. A year later, she became a faculty of bioinformatics of the institute where she holds the position of a professor. At IISc, she has set up a systems biology and computational biochemistry laboratory, popularly known as Chandralab, and hosts several research scholars. She also serves as a faculty at the National Network for Mathematical and Computational Biology, an educational agency funded by the Science and Engineering Research Board of the Government of India.

Legacy

Chandra's research focus is in the fields of computational systems biology, cell modeling and structural bioinformatics and she leads a team of scientists who are involved in research in areas such as systems biology, computational immunology, structural bioinformatics and drug discovery. She has carried out studies on Mycobacterium tuberculosis, the causative pathogen of tuberculosis, with special emphasis on their metabolic processes and, along with M. Vijayan and K. Sekar, two of her colleagues at IISc, has developed system models which has helped identify new drug targets against the disease. In 2017, the team led by her identified three drugs namely Ebselen, Vancomycin and Phenylarsine oxide that could be used in combination with Isoniazid, the principal antibiotic used against tuberculosis, to treat the drug-resistant strains of the pathogen. The team discovered that the three drugs lowered the antioxidant levels in the bacterium and thereby destroyed its drug-resistance. Her studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 297 of them. She has also delivered invited speeches at various seminars and conferences.

Awards and honors The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards in 2008.

Selected bibliography Bhagavat, Raghu; et al. (2018). "An Augmented Pocketome: Detection and Analysis of Small-Molecule Binding Pockets in Proteins of Known 3D Structure". Structure. 26 (3). Elsevier BV: 499–512.e2. doi:10.1016/j.str.2018.02.001. ISSN 0969-2126. PMID 29514079. Anand, Praveen; Chandra, Nagasuma (15 September 2014). "Characterizing the pocketome of Mycobacterium tuberculosis and application in rationalizing polypharmacological target selection". Scientific Reports. 4 (1): 6356. Bibcode:2014NatSR...4E6356A. doi:10.1038/srep06356. ISSN 2045-2322. PMC 5376175. PMID 25220818. Chandra, Nagasuma; Padiadpu, Jyothi (2013). "Network approaches to drug discovery". Expert Opinion on Drug Discovery. 8 (1): 7–20. doi:10.1517/17460441.2013.741119. PMID 23140510. S2CID 21595087. Bhagavat, Raghu; Chandra, Nagasuma (1 January 2014). "Common recognition principles across diverse sequence and structural families of sialic acid binding proteins". Glycobiology. 24 (1): 5–16. doi:10.1093/glycob/cwt063. ISSN 0959-6658. PMID 24043392.

Illustrations

Worked examples

Example 1 — a first encounter with Nagasuma Chandra

Start with the simplest possible case. Write down what Nagasuma Chandra claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In chemistry, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nagasuma Chandra before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nagasuma Chandra ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nagasuma Chandra

In research: Nagasuma Chandra appears in chemistry research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Nagasuma Chandra in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Nagasuma Chandra is common in secondary-school and first-year university syllabi. It links to neighbouring topics Academic staff of the Indian Institute of Science, Alumni of the University of Bristol, Bangalore University alumni, so understanding it makes those chapters shorter.
In everyday life: Look for Nagasuma Chandra outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Nagasuma Chandra in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Nagasuma Chandra means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
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Frequently asked questions

What is Nagasuma Chandra in simple terms?

Why does Nagasuma Chandra matter?

Because it connects several chemistry ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Nagasuma Chandra?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Nagasuma Chandra.