The National Nanotechnology Initiative (NNI) is a research and development initiative which provides a framework to coordinate nanoscale research and resources among United States federal government agencies and departments.
History In the late 1990's, nanotechnology was emerging as a particularly high potential field and President Bill Clinton advocated for federal nanotechnology development. In addition to Clinton himself, many credit Presidential Science Advisor Neal Lane and Mihail C. Roco of the NSF with championing an initiative in a 1999 presentation to the White House. In a 21 January 2000 speech [1] at the California Institute of Technology, Clinton stated that "Some of our research goals may take twenty or more years to achieve, but that is precisely why there is an important role for the federal government." The NNI was officially launched in 2000 and received funding for the first time in FY2001. President George W. Bush further increased funding for nanotechnology. On 3 December 2003 Bush signed into law the 21st Century Nanotechnology Research and Development Act (Pub. L. 108–153 (text) (PDF)), which authorizes expenditures for five of the participating agencies totaling $3.63 billion over four years.[2]. This law is an authorization, not an appropriation, and subsequent appropriations for these five agencies have not met the goals set out in the 2003 Act. However, there are many agencies involved in the Initiative that are not covered by the Act, and cumulative NNI funding since its inception in 2001 totals over $45 billion through the 2025 request. The National Nanotechnology Initiative has released Strategic Plans in 2004, 2007, 2011, 2014, 2016, and 2021 that outline goals and "program component areas," as required under the terms of the Act. In addition, the NNI community developed an environmental health and safety research strategy in 2011, which was significantly updated in 2024. This work expanded the scope of study on the impacts of nanotechnology to include incidental nanomaterials of concern, such as micro and nanoplastics and materials created through the use of 3D printers. The NNI annually prepares a Supplement to the President's Budget that summarize federal programmatic activities and address plans for the upcoming fiscal year. The Federal agencies with the largest investments are the National Institutes of Health, National Science Foundation, Department of Energy, Department of Defense, and the National Institute of Standards and Technology. The NNI received support for emerging technologies during the first Trump administration, particularly in the foundational role that nanotechnology plays in the emergence of quantum information technologies, artificial intelligence, and semiconductors. However, under Trump administration leadership, the activity and impact of NNI activities were scaled back. The Biden administration and new NNI leadership revitalized the nanotechnology community and interagency collaboration through a number of new programs, activities, and initiatives. In particular, they placed a special focus on clean energy and mitigating climate change through the Nano4EARTH challenge. They also expanded the NNI to recognize that nanotechnology has become pervasive in material, energy and biosystem related discoveries and applications. Other areas of interest included the study of micro and nanoplastics; ensuring greater accessibility and better networked user facilities; and strengthening and broadening interaction collaboration. The areas of emphasis and leadership from the first Trump administration continued into the second Trump administration.
Goals The five goals of NNI are:
Ensure that the United States remains a world leader in nanotechnology research and development. Promote commercialization of nanotechnology R&D. Provide the infrastructure to sustainably support nanotechnology research, development, and deployment. Engage the public and expand the nanotechnology workforce. Ensure the responsible development of nanotechnology.
Initiatives Throughout the history of the National Nanotechnology Initiative, there have been a variety of programs and challenges aimed at aligning the field with the highest priorities of the nation.
National Nanotechnology Challenges With the development of the most recent NNI Strategic Plan in 2021, the NNI created National Nanotechnology Challenges (NNC). The first NNC, Nano4EARTH, was announced by the White House Office of Science and Technology Policy (OSTP) on National Nanotechnology Day in 2022. Nano4EARTH was designed to mobilize the nanotechnology community to work across disciplines and stakeholder groups to accelerate the development, scale-up, and adoption of technologies to address challenges faced by the earth and its environment. The breadth and versatility of nanotechnology enable a unique opportunity to protect the earth and its environment, while increasing domestic energy efficiency. A two-day workshop identified four strategic areas of near-term opportunity: batteries and energy storage; catalysis; coatings, lubricants, membranes, and other interface technology; and capture of greenhouse gases. These topics have created a framework that has stimulated international discussion focused on the role nanotechnology and other emerging technologies can play in addressing climate and sustainability issues.
Examples of Previous Signature Initiatives and Grand Challenge Topics Water Sustainability through Nanotechnology – Nanoscale Solutions for a Global-Scale Challenge Nanotechnology for Sensors and Sensors for Nanotechnology – Improving and Protecting Health, Safety, and the Environment Sustainable Nanomanufacturing - Creating the Industries of the Future Nanoelectronics for 2020 and Beyond Nanotechnology for Solar Energy Collection and Conversion - Contributing to Energy Solutions for the Future Nanotechnology Knowledge Infrastructure - Enabling National Leadership in Sustainable Design Future Computing: Create a new type of computer that can proactively interpret and learn from data, solve unfamiliar problems using what it has learned, and operate with the energy efficiency of the human brain
Participating Federal Agencies and Departments Departments and agencies with nanotechnology R&D budgets: Other participating departments and agencies:
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