astronomy

Nicole Schupf

Nicole Schupf is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nicole Schupf rather than just read about it. In short: Nicole Schupf is an American epidemiologist and neuroscientist who is Professor of Epidemiology in Neurology, Psychiatry, the Gertrude H. Sergievsky Center, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Faculty of Medicine.

Key takeaways

Nicole Schupf belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Nicole Schupf to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Nicole Schupf from memory before moving on to harder problems.

Reference excerpt

Nicole Schupf is an American epidemiologist and neuroscientist who is Professor of Epidemiology in Neurology, Psychiatry, the Gertrude H. Sergievsky Center, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Faculty of Medicine. She studies aging and Alzheimer's disease in individuals with Down syndrome.

Education and early career Schupf graduated from Bryn Mawr College in 1964. She received her Ph.D. from New York University in 1970, trained as a physiological psychologist. She worked on neuroimmunological mechanisms in lupus cerebritis for several years before going on to pursue an M.P.H. from the University of California in 1984 and a Dr.P.H. in epidemiology from Columbia University, which she received in 1995.

Career Schupf is Professor of Epidemiology in Neurology, Psychiatry, the Gertrude H. Sergievsky Center, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Faculty of Medicine. She studies aging and Alzheimer's disease (AD) in individuals with Down syndrome (DS), looking at genetic and nongenetic factors that can influence degree of risk or age at onset. She is involved in longitudinal, multidisciplinary work searching for biomarkers that could define the progression of AD in this population. This wide-ranging investigation includes blood-based biomarkers (like beta-amyloid peptides, protein, inflammatory and lipid profiles); measures of amyloid and tau concentration in cerebrospinal fluid; changes detected with neuroimaging; PET studies of brain amyloid uptake; and genetic variations. She has been a major recipient of National Institutes of Health and other federal grant-makers for this research.

Selected publications Mayeux, R.; Honig, L. S.; Tang, M.-X.; Manly, J.; Stern, Y.; Schupf, N.; Mehta, P. D. (11 November 2003). "Plasma Aβ40 and Aβ42 and Alzheimer's disease: Relation to age, mortality, and risk". Neurology. 61 (9): 1185–1190. doi:10.1212/01.WNL.0000091890.32140.8F. ISSN 0028-3878. PMID 14610118. S2CID 54663454. Retrieved 3 January 2021. Manly, Jennifer J.; Tang, Ming-X.; Schupf, Nicole; Stern, Yaakov; Vonsattel, Jean-Paul G.; Mayeux, Richard (2008). "Frequency and course of mild cognitive impairment in a multiethnic community". Annals of Neurology. 63 (4): 494–506. doi:10.1002/ana.21326. ISSN 1531-8249. PMC 2375143. PMID 18300306. Kerkel, Kristi; Spadola, Alexandra; Yuan, Eric; Kosek, Jolanta; Jiang, Le; Hod, Eldad; Li, Kerry; Murty, Vundavalli V.; Schupf, Nicole; Vilain, Eric; Morris, Mitzi; Haghighi, Fatemeh; Tycko, Benjamin (July 2008). "Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation". Nature Genetics. 40 (7): 904–908. doi:10.1038/ng.174. ISSN 1546-1718. PMID 18568024. S2CID 10355545. Retrieved 3 January 2021. Scarmeas, Nikolaos; Stern, Yaakov; Mayeux, Richard; Manly, Jennifer J.; Schupf, Nicole; Luchsinger, Jose A. (1 February 2009). "Mediterranean Diet and Mild Cognitive Impairment". Archives of Neurology. 66 (2): 216–25. doi:10.1001/archneurol.2008.536. ISSN 0003-9942. PMC 2653223. PMID 19204158. Retrieved 3 January 2021. Scarmeas, Nikolaos; Luchsinger, José; Schupf, Nicole (12 August 2009). "Physical Activity, Diet, and Risk of Alzheimer Disease". JAMA. 302 (6): 627–37. doi:10.1001/jama.2009.1144. ISSN 0098-7484. PMC 2765045. PMID 19671904. Retrieved 3 January 2021.

Personal life Schupf was married to H. Jack Geiger from 1982 until his death in 2020.

References

Worked examples

Example 1 — a first encounter with Nicole Schupf

Start with the simplest possible case. Write down what Nicole Schupf claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nicole Schupf before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nicole Schupf ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nicole Schupf

In research: Nicole Schupf appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Nicole Schupf in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Nicole Schupf is common in secondary-school and first-year university syllabi. It links to neighbouring topics Alzheimer's disease researchers, American epidemiologists, American neuroscientists, so understanding it makes those chapters shorter.
In everyday life: Look for Nicole Schupf outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Nicole Schupf in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Nicole Schupf means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Nicole Schupf out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Nicole Schupf in simple terms?

Why does Nicole Schupf matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Nicole Schupf?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Nicole Schupf.