engineering

Nicotinate phosphoribosyltransferase

Nicotinate phosphoribosyltransferase is a engineering topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nicotinate phosphoribosyltransferase rather than just read about it. In short: In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O ⇌ {\displaystyle \rightleftharpoons } nicotinate D-ribonucleotide + diphosphate + ADP + phosphate Thus, the four substrates of this enzyme are nicotinate, 5-phospho-alpha-D-ribose 1-diphosphate, ATP, and H2O, whereas its four products are ni…

Key takeaways

Nicotinate phosphoribosyltransferase belongs to engineering; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
Connect Nicotinate phosphoribosyltransferase to a quantity you can measure, compute or draw — that is where exam questions come from.
Reproduce the core statement of Nicotinate phosphoribosyltransferase from memory before moving on to harder problems.

Reference excerpt

In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction

nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O ⇌ {\displaystyle \rightleftharpoons } nicotinate D-ribonucleotide + diphosphate + ADP + phosphate Thus, the four substrates of this enzyme are nicotinate, 5-phospho-alpha-D-ribose 1-diphosphate, ATP, and H2O, whereas its four products are nicotinate D-ribonucleotide, diphosphate, ADP, and phosphate. This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-phospho-alpha-D-ribose 1-diphosphate:nicotinate ligase (ADP, diphosphate-forming) .

Structural studies As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1VLP, PDB: 1YBE, PDB: 1YIR, PDB: 1YTD, PDB: 1YTE, PDB: 1YTK, and PDB: 2F7F.

References

IMSANDE J (1961). "Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli". J. Biol. Chem. 236 (5): 1494–7. doi:10.1016/S0021-9258(18)64203-6. PMID 13717628. IMSANDE J, HANDLER P (1961). "Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase". J. Biol. Chem. 236 (2): 525–30. doi:10.1016/S0021-9258(18)64397-2. PMID 13717627. Kosaka A, Spivey HO, Gholson RK (1971). "Nicotinate phosphoribosyltransferase of yeast. Purification and properties". J. Biol. Chem. 246 (10): 3277–83. doi:10.1016/S0021-9258(18)62224-0. PMID 4324895.

Illustrations

Worked examples

Example 1 — a first encounter with Nicotinate phosphoribosyltransferase

Start with the simplest possible case. Write down what Nicotinate phosphoribosyltransferase claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In engineering, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nicotinate phosphoribosyltransferase before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nicotinate phosphoribosyltransferase ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nicotinate phosphoribosyltransferase

In research: Nicotinate phosphoribosyltransferase appears in engineering research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Nicotinate phosphoribosyltransferase in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Nicotinate phosphoribosyltransferase is common in secondary-school and first-year university syllabi. It links to neighbouring topics EC 6.3.4, Enzymes of known structure, Ligase stubs, so understanding it makes those chapters shorter.
In everyday life: Look for Nicotinate phosphoribosyltransferase outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

Ask Teacher Smith questions about this articleOpens your AI tutor with a question about “Nicotinate phosphoribosyltransferase” →

Affiliate

Preply — study more efficiently by working with a personal tutor. 50% off.

How to study Nicotinate phosphoribosyltransferase in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Nicotinate phosphoribosyltransferase means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Nicotinate phosphoribosyltransferase out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Nicotinate phosphoribosyltransferase in simple terms?

In enzymology, a nicotinate phosphoribosyltransferase (EC 6.3.4.21) is an enzyme that catalyzes the chemical reaction nicotinate + 5-phospho-α-D-ribose 1-diphosphate + ATP + H2O ⇌ {\displaystyle \rightleftharpoons } nicotinate D-ribonucleotide + diphosphate + ADP + phosphate Thus, the four substrat…

Why does Nicotinate phosphoribosyltransferase matter?

Because it connects several engineering ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Nicotinate phosphoribosyltransferase?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Nicotinate phosphoribosyltransferase.