astronomy

Nihar Ranjan Jana

Nihar Ranjan Jana is a astronomy topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nihar Ranjan Jana rather than just read about it. In short: Nihar Ranjan Jana (born 1965) is an Indian neuroscientist and professor at the IIT Kharagpur, known for his studies on E3 ubiquitin ligases, protein homeostasis and neurodegenerative disorders. Jana is an elected fellow of the National Academy of Sciences, India.

Key takeaways

Nihar Ranjan Jana belongs to astronomy; place it in that map before memorising details.
Learn the definition first, then one example that makes the definition concrete.
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Reproduce the core statement of Nihar Ranjan Jana from memory before moving on to harder problems.

Reference excerpt

Nihar Ranjan Jana (born 1965) is an Indian neuroscientist and professor at the IIT Kharagpur, known for his studies on E3 ubiquitin ligases, protein homeostasis and neurodegenerative disorders. Jana is an elected fellow of the National Academy of Sciences, India. The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, in 2008 and TATA Innovation Fellowship in 2014 for his contributions to Neurodegenerative diseases.

Biography

Nihar Ranjan Jana, born in 1965, did his graduation (Midnapore College) and post graduation at Calcutta University, doctoral studies at the Visva-Bharati University and after securing a PhD in 1996, he completed his post-doctoral work at RIKEN Brain Science Institute, Japan. On his return to India, he joined the National Brain Research Centre (NBRC) as a faculty member in 2001. He served as faculty at National Brain Research Centre up to May 2018 and then moved to IIT Kharagpur, where he joined as Professor in the School of Bioscience. Jana resides in IIT Kharagpur, in West Bengal.

Legacy

Jana is involved in the research on neurological disorders caused by proteopathy and has carried out investigations on the role of E3 ubiquitin ligases as a causative factor. He has demonstrated how the ligases control cellular protein quality and how the absence of such an activity caused neuronal dysfunction or neurodegeneration. He led a team of scientists from NBRC and Bose Institute who conducted experiments on Huntington's disease, an inherited neurological disorder which led to the death of brain cells, and suggested azadiradione, a compound found in the seeds of Azadirachta indica (commonly known as neem) as a possible therapeutic molecule. He has also identified new targets in diseases such as Lafora disease, a form of epilepsy, autism and Angelman syndrome which has reportedly widened the understanding of their pathogenesis. His studies have been documented by way of a number of articles and ResearchGate, an online repository of scientific articles has listed 94 of them. Jana was a member of the Neurobiology Task force of the Department of Biotechnology. He has delivered keynote or invited speeches at seminars such as the International Conference on Neurodegenerative Diseases: Pathogenesis to Therapy - 2015 held at the Indian Institute of Science, Bengaluru and the IAN 2017 of the Indian Academy of Neurosciences held at Ravenshaw University, Cuttack.

Awards and honors The Department of Biotechnology of the Government of India awarded him the National Bioscience Award for Career Development, one of the highest Indian science awards in 2008 and the National Academy of Sciences, India elected him as a fellow the same year. He is also an elected fellow of the West Bengal Academy of Science and Technology and in 2012, he received the VASVIK Industrial Research Award for what the award citation mentioned as pioneering work on Huntington's disease. The award orations delivered by him include the 2013 edition of the K. T. Shetty Memorial Oration of the Indian Academy of Neurosciences.

Selected bibliography Singh, Brijesh Kumar; Vatsa, Naman; Nelson, Vinod K.; Kumar, Vipendra; Kumar, Shashi Shekhar; Mandal, Subhash C.; Pal, Mahadeb; Jana, Nihar Ranjan (2 January 2018). "Azadiradione Restores Protein Quality Control and Ameliorates the Disease Pathogenesis in a Mouse Model of Huntington's Disease". Molecular Neurobiology. 55 (8): 6337–6346. doi:10.1007/s12035-017-0853-3. ISSN 0893-7648. PMID 29294248. S2CID 12720344. Singh, Brijesh Kumar; Vatsa, Naman; Kumar, Vipendra; Shekhar, Shashi; Sharma, Ankit; Jana, Nihar Ranjan (15 October 2017). "Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer's disease". Human Molecular Genetics. 26 (20): 4042–4054. doi:10.1093/hmg/ddx295. ISSN 0964-6906. PMID 29016862.

Illustrations

Worked examples

Example 1 — a first encounter with Nihar Ranjan Jana

Start with the simplest possible case. Write down what Nihar Ranjan Jana claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In astronomy, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nihar Ranjan Jana before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nihar Ranjan Jana ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nihar Ranjan Jana

In research: Nihar Ranjan Jana appears in astronomy research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Nihar Ranjan Jana in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Nihar Ranjan Jana is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1965 births, Fellows of the National Academy of Sciences, India, Indian medical researchers, so understanding it makes those chapters shorter.
In everyday life: Look for Nihar Ranjan Jana outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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How to study Nihar Ranjan Jana in 20 minutes

Read the reference excerpt below once, without taking notes.
Close the page and write down what Nihar Ranjan Jana means in your own words.
Compare your version with the excerpt and mark what you missed.
Work through the three examples above with pen and paper.
Explain Nihar Ranjan Jana out loud to somebody else — or to Teacher Smith in the lgStudy chat.

Frequently asked questions

What is Nihar Ranjan Jana in simple terms?

Why does Nihar Ranjan Jana matter?

Because it connects several astronomy ideas at once: it gives you a definition you can apply, a quantity you can calculate, and a way to check whether a result is plausible.

How should I study Nihar Ranjan Jana?

Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

What does this page cover?

It gives you a compact reference excerpt plus original lgStudy explanations, examples, applications and study material on Nihar Ranjan Jana.