physics

Nilima Arun Kshirsagar

Nilima Arun Kshirsagar is a physics topic covered in the lgStudy science library. This page brings together a partial reference excerpt, illustrations, worked examples, real-world applications and a short study plan, so you can understand Nilima Arun Kshirsagar rather than just read about it. In short: Nilima Arun Kshirsagar (born 1949) is an Indian clinical pharmacologist who developed and patented liposomal amphotericin B and its drug delivery system in 1993. She is the former dean of King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College.

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Reference excerpt

Nilima Arun Kshirsagar (born 1949) is an Indian clinical pharmacologist who developed and patented liposomal amphotericin B and its drug delivery system in 1993. She is the former dean of King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College. She is the national chairperson in clinical pharmacology at Indian Council of Medical Research (ICMR) and president of the South Asian chapter of the American college of clinical pharmacology. She is a Member of the WHO Committees on Product development and Drug statistics Methodology. Kshirsagar is a fellow of the National Academy of Sciences, India, a fellow of the Searle Research Center, England, Faculty of Pharmaceutical Medicine UK and Fellow of American College of Clinical Pharmacology, USA. She is the Chair of the core training Panel of Pharmacovigilance Programme of India. She established departments of Clinical Pharmacology at KEM Hospital and at Nair Hospital Mumbai. The drug Liposomal Amphotericin-b, used to treat the Indian Mucormycosis epidemic of 2021 was developed and patented in India by Nalini Kshirsagar in 1993.

Career In 1977, after her doctorate she became assistant professor at King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College and she was promoted to associate professor in 1985. In 1993 she become a Professor and a Member of the steering committee of World Health Organization and a member of the advisory commission on product development and evaluate science program at Haffkine Institute. In 1993 she become the founding Head of the Department of Clinical Pharmacology at KEM, Mumbai, India. Kshirsagar was later made the Dean, the Professor and the Head of the Clinical Pharmacology department at King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College.

Notable work Bimal Kumar Bachhawat, Kshirsagar and Uttamchand Khimchand Sheth are credited with creating the research and academic structure for teaching pharmacology in India. Bachhawat encouraged Kshirsagar and Sunil Pandya to set up a liposome research laboratory. Under the leadership of Kshirsagar a new department of clinical pharmacology was set up at the KEM and at Nair Hospital Mumbai with financial help from the Brihanmumbai Municipal Corporation. Conventional amphotericin B was developed in the 1950s and for many decades it was the only antifungal agent available for the treatment of invasive fungal diseases. It was a standard care for a range of pathogenic fungus, however nephrotoxicity and infusion-related reactions was a major constraint. Kshirsagar and her team improved the techniques of the production of liposomes derived from soyabean Lecithin to make them usable in human beings. Liposomal amphotericin B, a lipid formulation of amphotericin B, was developed in India. Pharmacological and preclinical tests of liposomal amphotericin B drug delivery system were successful.

Use of liposomes as a delivery system for Amphotericin B was highly effective and less toxic as it carries the drug to the specific site and so it is required in much lower concentrations. After completion of the human trials, Kshirsagar defined the administration and dosing schedules. The product was patented and the technology was transferred through the National Research Development Corporation (NRDC) to a pharmaceutical company for marketing. This was the first drug development initiative of a Public–private partnership model in India. Liposomal Amphotericin-b was used as the primary treatment in the Mucormycosis epidemic of 2021 in India. During the COVID-19 pandemic in India there was a large increase of cases of what was named "black fungus" or mucormycosis in affected patients. Surgeons had to remove eyes after they were infected. One treatment was a daily injection for eight weeks of anti-fungal intravenous injection of amphotericin B. The injection could be standard amphotericin B deoxycholate or the liposomal form. Kshirsagar's liposomal form cost more but it was considered "safer, more effective and [with] lesser side effects". The World Health Organization (WHO) launched a global program to eliminate Lymphatic Filariasis in 2000. Kshirsagar's team of Indian scientists worked in two villages, Kurzadi and Selukate in Wardha, Maharashtra ensuring the safety and efficacy of the drugs. During her tenure as dean of King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College capacity was increased from 1,800 to 2,400 beds and the capacity of Intensive care unit beds was enhanced from 160 to 300. In 2017 Kshirsagar was appointed as chairperson of the expert committee constituted by the Drugs Controller General of India to elaborate on the parameters set out in section 26A of the Drugs and Cosmetics Act of India to decide whether to regulate, restrict or prohibit the sale of over 300 fixed-dose combination drugs in India. Based on a 700-page report submitted by the committee, the Supreme Court of India banned 328 fixed-dose combination drugs in September 2018.

Awards Dr. B. C. Roy Award for her work with drugs combating malaria, epilepsy, elephantiasis and heart diseases – (2002). Nathaniel T. Kwit memorial Awarde – (2018). Professor Archana Sharma Memorial Lecture Awardees – (2018). VASVIK Industrial Research Award- Smt. Chandaben Mohanbhai Patel Industrial Research Award for Women Scientists – (1997). Mumbai Mayors award for societal contribution.

Publications Nilima has produced over 200 publications:-

References

External links Swati, Lokhande (28 May 2021). "मराठी किमयागार! 10 फुटांच्या खोलीत झाला Mucormycosis वरील इंजेक्शनचा शोध; पाहा VIDEO". IBN lokmat TV. Retrieved 31 May 2021. Shrivastava, Shreya. "Vaccines – A Lemon and Spoon Race (Podcast with Dr Nilima Kshirsagar & Dr Dhvani Mehta) – Ep 1, Healthy Dose". Vidhi Centre for Legal Policy.

Worked examples

Example 1 — a first encounter with Nilima Arun Kshirsagar

Start with the simplest possible case. Write down what Nilima Arun Kshirsagar claims or describes in one sentence, then invent the smallest concrete situation in which that sentence is true. In physics, the smallest case is usually a single object, a single equation or a single measurement. Check that every symbol or term in your sentence has a meaning in that case.

Example 2 — changing one variable

Take the situation from Example 1 and change exactly one quantity: double it, halve it, or set it to zero. Predict what should happen to Nilima Arun Kshirsagar before you calculate. Comparing your prediction with the result is the fastest way to find out whether you understand the idea or only the words.

Example 3 — an exam-style question

Typical questions about Nilima Arun Kshirsagar ask you to (a) state it precisely, (b) apply it to given data, and (c) explain a limitation. Practise writing all three answers in under five minutes; the third part is what separates a full-mark answer from an average one.

Applications of Nilima Arun Kshirsagar

In research: Nilima Arun Kshirsagar appears in physics research whenever the underlying quantities have to be modelled precisely. Papers usually cite it as a starting assumption and then explore where it breaks down.
In technology and industry: Engineering practice reuses Nilima Arun Kshirsagar in design rules, simulations and safety margins. Knowing the idea lets you read a specification sheet and understand why the numbers look the way they do.
In the classroom: Nilima Arun Kshirsagar is common in secondary-school and first-year university syllabi. It links to neighbouring topics 1949 births, 20th-century Indian biologists, 20th-century Indian medical doctors, so understanding it makes those chapters shorter.
In everyday life: Look for Nilima Arun Kshirsagar outside the textbook — in sport, cooking, traffic, electronics or the sky above you. An example you found yourself is remembered far longer than one you were given.

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Frequently asked questions

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Read the excerpt, restate it from memory, then work through the examples and applications listed on this page. The five-step study plan above takes about twenty minutes.

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