Nuclear atypia refers to abnormal appearance of cell nuclei. It is a term used in cytopathology and histopathology. Atypical nuclei are often pleomorphic. Nuclear atypia can be seen in reactive changes, pre-neoplastic changes, and malignancy. Severe nuclear atypia is, in most cases, considered an indicator of malignancy.
See also Arias-Stella reaction NC ratio Nuclear pleomorphism
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