Nucleobindin-1 (NUCB1), also known as calnuc, is a protein that in humans is encoded by the NUCB1 gene.
Structure The human calnuc protein contains 461 amino acids and has a pI of 4.9. The protein contains the following regions and domains:
Signal peptide Leucine-zipper The leucine-zipper of calnuc may be responsible for its dimerization. aa 347-389 – Nuclear localization signal 2 zinc binding sites with high affinity (Kd = 20 nM) carboxypeptidase-like motifs : HFREXnH (aa 66) and HFTEXnH (aa 146) 2 EF-hands Potential anchor region– 15-aa hydrophobic region at its COOH terminus that may be sufficient for membrane anchoring
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